Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain

Zembrzycki, Andreas; Griesel, Gundula; Stoykova, A.; Mansouri, Ahmed

doi:10.1186/1749-8104-2-8

Cited by 96 publications

(102 citation statements)

References 53 publications

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“…27 It is a crucial developmental event as the neocortical areas form the basis for sensory perception, control of movements and mediate our behavior. 28 The gene ST8SIA2 (previously known as SIAT8B) located close to rs8040009 on a hypothetical protein C15orf32, whose role in the pathogenesis of bipolar I disorder is not clear.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study of bipolar I disorder in the Han Chinese population

et al. 2010

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We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 a-Nacetyl-neuraminide a-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with Pvalues of 4.87 Â 10 À7 (rs2709736) and 6.05 Â 10 À6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P = 9.74 Â 10 À6 ) and in CACNB2 (Calcium channel, voltage-dependent, b-2 subunit) gene (rs11013860, P = 5.15 Â 10 À5 ), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P = 6.55 Â 10 À5 and P = 1.48 Â 10 À5 , respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

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Section: Discussionmentioning

confidence: 99%

Genome-wide association study of bipolar I disorder in the Han Chinese population

et al. 2010

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“…Coup-TF1 is expressed in greatest concentration in caudal-lateral regions, while SP8 is expressed in rostral-medial regions. As was the case with Pax6 and Emx2, blocking the expression of these genes results in dramatic alteration in the sensorimotor organization of the neocortex (O'Leary et al 2007;Zembrzycki et al 2007; O' Leary and Sahara 2008;Sansom and Livesey 2009).…”

Section: Neural Patterning In the Embryonic Periodmentioning

confidence: 99%

The Basics of Brain Development

Stiles¹,

Reilly²,

Levine³

et al. 2012

Neural Plasticity and Cognitive Development

235

291

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Over the past several decades, significant advances have been made in our understanding of the basic stages and mechanisms of mammalian brain development. Studies elucidating the neurobiology of brain development span the levels of neural organization from the macroanatomic, to the cellular, to the molecular. Together this large body of work provides a picture of brain development as the product of a complex series of dynamic and adaptive processes operating within a highly constrained, genetically organized but constantly changing context. The view of brain development that has emerged from the developmental neurobiology literature presents both challenges and opportunities to psychologists seeking to understand the fundamental processes that underlie social and cognitive development, and the neural systems that mediate them. This chapter is intended to provide an overview of some very basic principles of brain development, drawn from contemporary developmental neurobiology, that may be of use to investigators from a wide range of disciplines.

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“…The removal of Sp8 from the developing cortex results in a significant expansion of caudal areas at the expense of rostral areas, as assessed by cortical plate marker expression and corticalthalamic connectivity (Fig. 3B) (Zembrzycki et al 2007). Sp8 is induced by FGF8 and can reciprocally regulate the expression of FGF8 (Sahara et al 2007).…”

Section: Gradients Of Transcription Factors Refine Area Patterningmentioning

confidence: 99%

“…In the developing neocortex, these transcription factors are expressed in nested rostralhigh to caudal-low gradients and the expression of these factors can be decreased or increased by reducing or augmenting the rostral FGF source (Fukuchi-Shimogori and Grove 2003). Finally, two other genes, the transcription factor Sp8 and the imprinted gene Mest/Peg1, the expression of which is induced by FGF signaling in the neocortex, are also expressed in rostralhigh to caudal gradient across the neocortical primordium (Sansom et al 2005;Sahara et al 2007;Zembrzycki et al 2007). …”

Section: Secreted Growth Factors Pattern the Rostrocaudal Axis Of Thementioning

confidence: 99%

Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex

Sansom

Livesey

2009

Cold Spring Harbor Perspectives in Biology

136

107

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In the developing brain, gradients are commonly used to divide neurogenic regions into distinct functional domains. In this article, we discuss the functions of morphogen and gene expression gradients in the assembly of the nervous system in the context of the development of the cerebral cortex. The cerebral cortex is a mammal-specific region of the forebrain that functions at the top of the neural hierarchy to process and interpret sensory information, plan and organize tasks, and to control motor functions. The mature cerebral cortex is a modular structure, consisting of anatomically and functionally distinct areas. Those areas of neurons are generated from a uniform neuroepithelial sheet by two forms of gradients: graded extracellular signals and a set of transcription factor gradients operating across the field of neocortical stem cells. Fgf signaling from the rostral pole of the cerebral cortex sets up gradients of expression of transcription factors by both activating and repressing gene expression. However, in contrast to the spinal cord and the early Drosophila embryo, these gradients are not subsequently resolved into molecularly distinct domains of gene expression. Instead, graded information in stem cells is translated into discrete, region-specific gene expression in the postmitotic neuronal progeny of the stem cells.

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Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain

Cited by 96 publications

References 53 publications

Genome-wide association study of bipolar I disorder in the Han Chinese population

Genome-wide association study of bipolar I disorder in the Han Chinese population

The Basics of Brain Development

Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex

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