Genetic Factors Involved in Mandibular Prognathism

Doraczyńska-Kowalik, Anna; Nelke, Kamil; Pawlak, Wojciech; Sasiadek, Maria M.; Gerber, Hanna

doi:10.1097/scs.0000000000003627

Cited by 61 publications

(65 citation statements)

References 59 publications

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“…It has also been reported that there is a left-right difference in the phenotype of muscle, such as contraction characteristics 16) . It is thought that genetic factors are involved in the onset of jaw deformities 2,3,17) ; however, it is difficult to explain left-right morphological differences, and it is assumed that some acquired, habitual, or local factors are also involved. Since hyperplasia of the mandibular head may be involved in neoplasia, hyper-/hypoplasia of the mandibular head was excluded from this study.…”

Section: Discussionmentioning

confidence: 99%

Masseter Muscle Properties Differ between the Left and Right Sides in Mandibular Class III Patients with Asymmetry

Nakashima

Yamada

Sugiyama

et al. 2020

J. Hard Tissue Biology.

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In this study on muscle characteristics and jawbone morphology, the relationship between masticatory muscle properties and jaw deformity was analysed in skeletal Class III patients with asymmetry. The subjects were 27 patients (21 women and 6 men) who had skeletal mandibular prognathism with mandibular asymmetry. The subjects' ages ranged from 16 to 51 years, with an average of 23.5 years. Patients with lateral displacement of Me 3 mm or more and an ANB angle of 0 ° or less were included. Morphometric measurements were taken from CT images. Biopsy material was collected during surgery for immunohistological typing of muscle fibres, MyHC1, 2a, and 2x isoforms; measurement of MYH1, 2, 7, 8 mRNA expression. In CT morphometry, there was no difference in muscle thickness or cross-sectional area between the deviated and non-deviated sides, but both sides tended to have thinner muscles than the control group. In the typing of muscle fibres by immunohistochemical staining, type 2 fibres were found to be significantly more numerous on the deviated side than on the non-deviated side. Regarding protein quantities, MyHC1 was more abundant on the deviated side than on the non-deviated side. Regarding the expression of mRNA, MYH7 (type 1) and MYH1 (type 2x) showed no difference between the two sides, and MYH2 (type 2a) had a higher expression level on the deviated side than in the control group. The data suggested a tendency for Class III patients to have characteristics of a short face on the deviated side, and a long face on the non-deviated side. It seems that muscle type switching may be in progress.

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Section: Discussionmentioning

confidence: 99%

Masseter Muscle Properties Differ between the Left and Right Sides in Mandibular Class III Patients with Asymmetry

Nakashima

Yamada

Sugiyama

et al. 2020

J. Hard Tissue Biology.

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“…S obzirom na to da je naš pacijent progeničar i prošao je pubertetski vrhunac rasta, on je kandidat za ortognatsku kirurgiju 6 . Progenija ili mandibularni prognatizam je nasljedna skeletna malokluzija [6][7][8] . U našoj populaciji je zastupljena oko 5 % u trajnoj denticiji 9 .…”

Section: Raspravaunclassified

3D planiranje terapije lica – prikaz slučaja

Dekanić

Volf

Maričić³

et al. 2020

Med. Flum. (Online)

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Cilj: Prikazati kako je uporabom suvremenih tehnologija omogućena 3D virtualna priprema i praćenje pacijenta prije, tijekom i nakon zahvata. Prikaz slučaja: Prikazan je pacijent s pravom progenijom, dakle skeletnom klasom III, obrnutim prijeklopom, zbijenošću zuba i konkavnim profilom kojemu su ortodontskom terapijom zuba pripremljeni za ortognatski kirurški zahvat koji je potom izvršen na gornjoj i donjoj čeljusti (LeFort I i BSSO). Dijagnostički postupak i evaluacija ishoda, osim standardnog protokola, uključivao je i pripremu za 3D virtualno planiranje. Učinjeno je skeniranje studijskih modela, CBCT snimak, 3D fotografije i analize pomoću 3D softvera. Kirurške vodilice napravljene su 3D printerom. Zaključak: Korištenjem suvremenih tehnologija i 3D virtualnog planiranja olakšan je i skraćen postupak planiranja ishoda i praćenje rezultata terapije uz veliku preciznost u izradi kirurških vodilica.

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“…caries, injuries, oral parafunctions (such as bruxism) [5,6,7]. The aetiology of malocclusion is primarily genetic [8,9,10]. Possible etiologies include genetic and environmental factors or a combination of both [11].…”

Section: Introductionmentioning

confidence: 99%

Late postoperative complications and dysfunction of the stomatognathic system (SS) in patients after orthognathic surgery

Górska

Gębska

2020

J Educ Health Sport

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Introduction: Patients with maxillofacial and intraoral defects require orthognathic surgery to improve the appearance of the face and correct the occlusion. The number of orthognathic surgeries has been increasing in recent years. The motivation to undergo these surgeries is the possibility for patients to improve stomatognathic system functions i.e. chewing, swallowing and pronunciation, as well as aesthetic and psychosocial factors. Aim: The aim of the paper was to assess the occurrence of late postoperative complications and dysfunction of the stomatognathic system in patients after orthognathic surgeries such as Maxillary Lefort 1 Osteotomy and Bilateral Sagittal Split Osteotomy (BIMAX). Additionally, the paper emphasizes the necessity of quick activation of the stomatognathic system structures in patients after orthognathic surgeries in order to reduce the incidence of complications. Material and methods: The research was conducted with the help of the users of internet groups: "Progenia, mandibular prognathism, photos BEFORE and AFTER the operation :)" (in Polish: "Progenia, wysunięta szczęka, zdjęcia PRZED i PO operacji :)") and "Suffering from progenia" ("Progenicy") as well as users of the Jawsurgeryforums.com online forum who have given their informed consent to participate in the survey. The analysis was carried out on a group of 92 people who underwent orthognathic surgery of Maxillary Lefort 1 Osteotomy and Bilateral Sagittal Split Osteotomy (BIMAX) type in the years 2004-2019. To assess the opinions of patients, a diagnostic questionnaire method was used, based on a proprietary electronic questionnaire, which consisted of three parts. The first part is metric, i.e.: age, gender and questions concerning the number of orthognathic surgeries performed, time of wearing intermaxillary traction wiring or splints, postoperative rehabilitation. The second part of the questionnaire consisted of 15 close-ended questions assessing the occurrence of symptoms of SS system disorders and functioning. The third part of the questionnaire consists of 20 questions concerning postoperative complications after 3 and 6 months from surgery and functioning of the dental system after surgery. The fourth part of the questionnaire consists of 5 close-ended questions concerning the evaluation of the overall impression after surgery and the most important effects of it. The test results were statistically analyzed using the correlation coefficient and Pearson's chi-squared test (p ≤ 0.05). Results: 92 people, of which 86 women (93.5%) and 6 men (6.5%), participated in the study. The most common ailments before the surgeryaffecting more than half of the patientswere chewing impairment, speech defect, breathing problems and headaches. 3 months after the operation, facial neurosensory disturbances and facial swelling were the most frequent of the ailments reported by the patients (more than 70% of the respondents), limited jaw mobility, joint pains and chewing impairment were also frequent (more than 40%). 6 months after the s...

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Genetic Factors Involved in Mandibular Prognathism

Cited by 61 publications

References 59 publications

Masseter Muscle Properties Differ between the Left and Right Sides in Mandibular Class III Patients with Asymmetry

Masseter Muscle Properties Differ between the Left and Right Sides in Mandibular Class III Patients with Asymmetry

3D planiranje terapije lica – prikaz slučaja

Late postoperative complications and dysfunction of the stomatognathic system (SS) in patients after orthognathic surgery

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