Genetic factors in the development of chronic kidney disease in patients with diabetes mellitus

Vikulova, Olga K.; Zheleznyakova, Anna V.; Лебедева, Надежда Олеговна; Никитин, А Г; Носиков, В. В.; Shestakova, Marina V.

doi:10.1134/s1022795417030140

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…In early years, linkage analyses and candidate gene screen indeed identified a few T2DM risk genes, such as calpain 10 [79], transcription factor 7-like 2 [80], peroxisome proliferator-activated receptor gamma [81], insulin receptor substrate 1 [82,83], and angiotensin-converting enzyme [84,85]. It was found that the genetic peculiarity of T2DM was a high frequency of alleles with low or average effect for DKD predisposition [86]. Because the frequencies of these variants differ significantly among various ethnic groups, the population risk also differs [86].…”

Section: The Focus On Translational Medicine Of Dkd: From the Nightmamentioning

confidence: 99%

“…It was found that the genetic peculiarity of T2DM was a high frequency of alleles with low or average effect for DKD predisposition [86]. Because the frequencies of these variants differ significantly among various ethnic groups, the population risk also differs [86]. However, the overall contributions of these approaches to the study of T2DM heritability remained underpowered, and some results were conflicting.…”

Section: The Focus On Translational Medicine Of Dkd: From the Nightmamentioning

confidence: 99%

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Diabetic kidney diseases revisited: A new perspective for a new era

Fu¹,

Liu

Bastacky

et al. 2019

Molecular Metabolism

149

115

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BackgroundGlobally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, clinical problem in terms of its diagnosis and management. Intensive glucose control in DKD could slow down but not significantly halt disease progression. Revisiting the tremendous advances that have occurred in the field would enhance recognition of DKD pathogenesis as well as improve our understanding of translational science in DKD in this new era.Scope of reviewIn this review, we summarize advances in the understanding of the local microenvironmental changes in diabetic kidneys and discuss the involvement of genetic and epigenetic factors in the pathogenesis of DKD. We also review DKD prevalence changes and analyze the challenges in optimizing the diagnostic approaches and management strategies for DKD in the clinic. As we enter the era of ‘big data’, we also explore the possibility of linking systems biology with translational medicine in DKD in the current healthcare system.Major conclusionNewer understanding of the structural changes of diabetic kidneys and mechanisms of DKD pathogenesis, as well as emergent research technologies will shed light on new methods of dealing with the existing clinical challenges of DKD.

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Section: The Focus On Translational Medicine Of Dkd: From the Nightmamentioning

confidence: 99%

Section: The Focus On Translational Medicine Of Dkd: From the Nightmamentioning

confidence: 99%

Diabetic kidney diseases revisited: A new perspective for a new era

Fu¹,

Liu

Bastacky

et al. 2019

Molecular Metabolism

149

115

View full text Add to dashboard Cite

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TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups

et al. 2022

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Investigation of the frequencies of functionally signif icant gene variants in the context of medical biology and gene geography is a relevant issue for studying the genetic structure of human populations. The transition from a traditional to an urbanized lifestyle leads to a higher incidence of civilizational diseases associated with metabolic disorders, including type 2 diabetes mellitus. The goal of the present paper is to analyze the frequencies of functionally signif icant gene alleles in the metabolic prof iles of indigenous Siberian peoples to identify the gene pool resilience, evaluate the susceptibility of various ethnic groups to metabolic disorders under changing environmental conditions, and predict the epidemiological situation that may occur in the near future. The study was performed in the monoethnic samples of eastern and western Buryats, Teleuts, Dolgans, and two territorial groups of Yakuts. A real-time PCR was used to determine the frequencies of single nucleotide polymorphisms (SNPs) G103894T, rs12255372, and C53341T, rs7903146 in the TCF7L2 gene. The results obtained were compared to the frequencies identif ied for Russians from Eastern Siberia and the values available in the literature. The frequencies of the polymorphic variants studied in the samples from the indigenous Siberian peoples place them in between Caucasian and East Asian populations, following the geographic gradient of polymorphism distribution. A signif icantly lower occurrence of type 2 diabetes risk alleles TCF7L2 (103894T) and TCF7L2 (53341T) in the samples of indigenous Siberian peoples compared to Russians was observed, which agrees with their lower susceptibility to metabolic disorders compared to the newcomer Caucasian population. Taking into account urbanization, a reduced growth in type 2 diabetes incidence may be predicted in indigenous Siberian peoples, i. e. Buryats, Yakuts, Dolgans, and Teleuts, compared to the newcomer Caucasian population. A further study of population structure with respect to different metabolic prof ile genes is required to better understand the molecular genetic foundations of the adaptive potential of indigenous Siberian peoples.

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Genetic factors in the development of chronic kidney disease in patients with diabetes mellitus

Cited by 2 publications

References 43 publications

Diabetic kidney diseases revisited: A new perspective for a new era

Diabetic kidney diseases revisited: A new perspective for a new era

TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups

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