Genetic evidence for an East Asian origin of Chinese Muslim populations Dongxiang and Hui

Yao, Hongbing; Wang, Chuan‐Chao; Tao, Xiaolan; Shang, Lei; Wen, Shaoqing; Zhu, Bofeng; Kang, Longli; Jin, Li; Li, Hui

doi:10.1038/srep38656

Cited by 40 publications

(36 citation statements)

References 41 publications

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“…The West Eurasian related Y‐chromosomal lineages in the Hui samples collected from Xinjiang reach a high frequency of 35.29%, but the West Eurasian related mtDNA lineages only comprise 6.7% of the Hui gene pool in Xinjiang as reported before (Y. G. Yao et al, ). We also have not found such a high proportion of West Eurasian gene flow on autosomal STRs compared with that from paternal Y chromosome (H. B. Yao et al, ). Therefore, we suspect the admixture in Hui people was probably a sex‐biased male‐driven process.…”

Section: Discussionmentioning

confidence: 72%

“…The paternal Y‐chromosomal short tandem repeat (STR) clustering suggests there is an affinity between the Hui people of Liaoning in northeastern China and Ningxia in northwestern China with Sino‐Tibetan speaking East Asian populations (Zhang, Li, Huang, Lu, & Hu, ). The study of autosomal STRs of Hui in Gansu province in northwest China also shows no evidence of substantial gene flow from the Middle East or Europe into the Hui people during their Islamization (H. B. Yao et al, ). The maternal mtDNA profile shows only about 6.7% of the lineages in Hui people of Xinjiang in northwest China having West Eurasian origin (Y. G. Yao, Kong, Wang, Zhu, & Zhang, ).…”

Section: Introductionmentioning

confidence: 99%

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The massive assimilation of indigenous East Asian populations in the origin of Muslim Hui people inferred from paternal Y chromosome

Wang

Lü²,

Kang

et al. 2019

American J Phys Anthropol

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Objectives: The Hui people are the adherents of Muslim faith and distributing throughout China.There are two contrasting hypotheses about the origin and diversification of the Hui people, namely, the demic diffusion involving the mass movement of people or simple cultural diffusion. Materials and methods:We collected 621 unrelated male individuals from 23 Hui populations all over China. We comprehensively genotyped more than 100 informative Y-chromosomal single nucleotide polymorphisms and 17 Y-chromosomal short tandem repeats (STRs) on those samples.Results: Co-analyzed with published worldwide populations, our results suggest the origin of Hui people has involved massive assimilation of indigenous East Asians with about 70% in total of the paternal ancestry could be traced back to East Asia and the left 30% to various regions in West Eurasia.Discussion: The genetic structure of the extant Hui populations was primarily shaped by the indigenous East Asian populations as they contribute the majority part of the paternal lineages of Hui people. The West Eurasian admixture was probably a sex-biased male-driven process since we have not found such a high proportion of West Eurasian gene flow on autosomal STRs and maternal mtDNA.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

The massive assimilation of indigenous East Asian populations in the origin of Muslim Hui people inferred from paternal Y chromosome

Wang

Lü²,

Kang

et al. 2019

American J Phys Anthropol

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“…However, compared with Uigur, a typical admixture of eastern and western Eurasians in both anthropometric and genetic traits [5], the origin of Hui has long been a controversial issue. Through the analysis of 15 autosomal short tandem repeats (STRs), Hui in Linxia, Gansu province, showed significant genetic homogeneity with East Asian populations [6]. This conclusion was also supported by the study of some other autosomal markers, such as human leukocyte antigen (HLA) class I polymorphisms [7].…”

Section: Introductionmentioning

confidence: 87%

Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci

et al. 2020

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According to historical records, ethnic Hui in China obtained substantial genetic components from western Eurasian populations during their Islamization. However, some scholars believed that the ancestry of Hui people were native Chinese populations. In this context, the formation of Hui is due to simple cultural diffusion rather than demic diffusion. In this study, we examined the forensic and population genetic application of the 30 InDel loci in Hui population from Ningxia Hui Autonomous Region, Northwest China. Genotype analysis of 129 unrelated individuals revealed that all loci were in the Hardy–Weinberg equilibrium in Ningxia Hui. Forensic indices calculated from genotypes demonstrated that this panel, Qiagen DIPplex ® Investigator kit, was powerful enough to be used in individual identification but not in paternity cases. Through population genetic analysis, we found that Ningxia Hui received much more genetic contributions from East Asian populations than those from western Eurasian populations. Finally, we statistically identified the admixture signal of eastern and western Eurasians, although the latter is weak, in Ningxia Hui via the three-population test. All this evidence suggested that the formation of Ningxia Hui was mainly attributed to the cultural transformation of local Chinese residents with minor gene flow from western Eurasian populations.

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“…Tests for Hardy–Weinberg equilibrium were performed in Arlequin v3.5.1.319. Since the statistical analyses in this study were on the basis of Bayesian-clustering algorithm, raw genotypic data of 13 STRs (excluding D6S1043 and D12S391) from 59 populations all around the world were extracted to determine population affinity1420212223242526272829303132333435363738394041424344454647484950. Analysis of molecular variance (AMOVA), average number of pairwise differences, pairwise Fst, Slatkins linearized Fst, and coancestry coefficients were all calculated in Arlequin v3.5.1.319 using genotype data.…”

Section: Methodsmentioning

confidence: 99%

Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci

Yao

Wang

et al. 2017

Sci Rep

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The origin and diversification of Sino-Tibetan speaking populations have been long-standing hot debates. However, the limited genetic information of Tibetan populations keeps this topic far from clear. In the present study, we genotyped 15 forensic autosomal short tandem repeats (STRs) from 803 unrelated Tibetan individuals from Gansu Province (635 from Gannan and 168 from Tianzhu) in northwest China. We combined these data with published dataset to infer a detailed population affinities and genetic substructure of Sino-Tibetan populations. Our results revealed Tibetan populations in Gannan and Tianzhu are genetically very similar with Tibetans from other regions. The Tibetans in Tianzhu have received more genetic influence from surrounding lowland populations. The genetic structure of Sino-Tibetan populations was strongly correlated with linguistic affiliations. Although the among-population variances are relatively small, the genetic components for Tibetan, Lolo-Burmese, and Han Chinese were quite distinctive, especially for the Deng, Nu, and Derung of Lolo-Burmese. Han Chinese but not Tibetans are suggested to share substantial genetic component with southern natives, such as Tai-Kadai and Hmong-Mien speaking populations, and with other lowland East Asian populations, which implies there might be extensive gene flow between those lowland groups and Han Chinese after Han Chinese were separated from Tibetans. The dataset generated in present study is also valuable for forensic identification and paternity tests in China.

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Genetic evidence for an East Asian origin of Chinese Muslim populations Dongxiang and Hui

Cited by 40 publications

References 41 publications

The massive assimilation of indigenous East Asian populations in the origin of Muslim Hui people inferred from paternal Y chromosome

The massive assimilation of indigenous East Asian populations in the origin of Muslim Hui people inferred from paternal Y chromosome

Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci

Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci

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