Arch Gen Psychiatry
 1974
DOI: 10.1001/archpsyc.1974.01760160019005
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Genetic Determinant of Lithium Ion Distribution

Elizabeth Dorus
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Cited by 60 publications

(8 citation statements)
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“…39 The concentration ratio was assumed to be a heritable trait underlying propensity to BD, 40,41 but these hypotheses were not confirmed by later studies. Moreover, it was subsequently discovered that lithium is not distributed in the brain (or even in neurons) evenly, questioning the relevance of the lithium ratio, especially if measured in peripheral cells.…”
Section: Mechanisms
mentioning
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…39 The concentration ratio was assumed to be a heritable trait underlying propensity to BD, 40,41 but these hypotheses were not confirmed by later studies. Moreover, it was subsequently discovered that lithium is not distributed in the brain (or even in neurons) evenly, questioning the relevance of the lithium ratio, especially if measured in peripheral cells.…”
Section: Mechanisms
mentioning
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Initial twin studies concluded that there is a genetic component to the interindividual variation in transport (Dorus, Pandey & Davis, 1975;Mendlewicz et al, 1978). In these experiments the concordance in the RBC-to-plasma Li + ratio between pairs of monozygotic twins was significantly greater than between pairs of dizygotic twins.…”
Section: Changes In Rbc
mentioning
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Lithium treatment also seemed to worsen epileptic episodes in patients with epilepsy [153]. Researchers believe that there is a genetic component to the uptake of lithium in the brain, and some people are at a genetic predisposition to take up lithium more easily [154]. Previously damaged brain matter is also not as effective at removing lithium as healthy tissue [156].…”
mentioning
confidence: 99%
“…Levels continue to rise for another 12-14 hours after an initial 12-hour measure of the serum. Instead, more accurate levels of lithium in the brain are portrayed by intra-erythrocyte levels [154].…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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