Genetic changes in pT2 and pT3 prostate cancer detected by comparative genomic hybridization

Fukasawa, Satoshi; Kino, Mika; Kobayashi, Masayoshi; Suzuki, Hiroyoshi; Komiya, Akira; Igarashi, Takashi; Hirokawa, Yoshifumi; Shiraishi, Taizo; Takao, Masaki; Ishida, H; Shindo, Takayuki; Seki, Naohiko; Ichikawa, Tomohiko

doi:10.1038/sj.pcan.4501017

Cited by 5 publications

(6 citation statements)

References 37 publications

(43 reference statements)

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“…This data is in agreement with previous studies of prostate cancer in American [15] and Japanese populations [12] . Previous studies of prostate cancer in Japanese patients suggest that LOH of 13q14 is more frequent in metastatic foci than in primary tumors [18] , and losses of 13q14-31 are observed more frequently in pT3 tumors than in pT2 tumors [12] . These previous results, together with our data, may indicate that loss of 13q14 plays an important role in tumor progression of prostate cancer.…”

Section: Discussionsupporting

confidence: 83%

Genetic Alterations at 13q14 May Correlate with Differences in the Biological Behavior of Prostate Cancer between Japanese and Caucasian Men

Misumi¹,

Yamamoto²,

Murakami

et al. 2010

Urol Int

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The incidence of prostate cancer and the resultant mortality rates in Japanese men are lower compared with the rates for Caucasians; however, the Gleason score at diagnosis is higher in Japanese men compared with Caucasians. Loss of 13q is one of the most common chromosomal alterations in prostate cancer. To elucidate the difference in the rate of loss of 13q between Japanese and Caucasian men, we examined the allelic imbalance (AI) on chromosome 13q in 32 Japanese and 39 German prostate cancer patients with a fluorescent polymerase chain reaction technique using 12 microsatellite markers. Benign and malignant histology was identified by a single pathologist and laser capture microdissection was used to gather cancer cells. Although there were no statistical differences in patient background characteristics, the frequency of AI at 13q14 (D13S1253) and at 13q21 (D13S166) was significantly higher in Japanese patients compared with German patients (p = 0.0128 and p = 0.0078, respectively). The frequency of AI at 13q14 was significantly higher in tumors with high Gleason scores (GS) compared with tumors with low GS (p = 0.0478). The present observations suggest that the frequency of genetic alterations at 13q14 may underlie differences in the biological behavior of prostate cancer between Japanese and Caucasian populations.

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Section: Discussionsupporting

confidence: 83%

Genetic Alterations at 13q14 May Correlate with Differences in the Biological Behavior of Prostate Cancer between Japanese and Caucasian Men

Misumi¹,

Yamamoto²,

Murakami

et al. 2010

Urol Int

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“…Both deletions 29 and amplifications 30 of 17q21 have been described in prostate-cancer specimens. However, such analyses need to be performed in tumors from known HOXB13 G84E carriers.…”

Section: Discussionmentioning

confidence: 99%

Germline Mutations inHOXB13and Prostate-Cancer Risk

Ewing

Ray

Lange³

et al. 2012

N Engl J Med

582

519

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BACKGROUND Family history is a significant risk factor for prostate cancer, although the molecular basis for this association is poorly understood. Linkage studies have implicated chromosome 17q21-22 as a possible location of a prostate-cancer susceptibility gene. METHODS We screened more than 200 genes in the 17q21-22 region by sequencing germline DNA from 94 unrelated patients with prostate cancer from families selected for linkage to the candidate region. We tested family members, additional case subjects, and control subjects to characterize the frequency of the identified mutations. RESULTS Probands from four families were discovered to have a rare but recurrent mutation (G84E) in HOXB13 (rs138213197), a homeobox transcription factor gene that is important in prostate development. All 18 men with prostate cancer and available DNA in these four families carried the mutation. The carrier rate of the G84E mutation was increased by a factor of approximately 20 in 5083 unrelated subjects of European descent who had prostate cancer, with the mutation found in 72 subjects (1.4%), as compared with 1 in 1401 control subjects (0.1%) (P = 8.5×10−7). The mutation was significantly more common in men with early-onset, familial prostate cancer (3.1%) than in those with late-onset, nonfamilial prostate cancer (0.6%) (P = 2.0×10−6). CONCLUSIONS The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. Although the variant accounts for a small fraction of all prostate cancers, this finding has implications for prostate-cancer risk assessment and may provide new mechanistic insights into this common cancer. (Funded by the National Institutes of Health and others.)

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“…Array‐based genome‐wide gene expression analysis and DNA copy number analysis have shown tumor‐suppressive genes, such as PTEN , ATBF , KLF5 and KLF6 , and oncogenic genes, such as c‐MYC , AR and TEMPRESS/ERG , that contribute to PCa oncogenesis . Recent high‐resolution array of comparative genomic hybridization (array‐CGH) studies have identified several chromosomal alterations using PCa cell lines and primary tissues . Among these chromosomal deletion or amplification regions, novel cancer‐related genes or miRNA might exist.…”

Section: Chromosome Mapping Of Aberrantly Expressed Mirna In Pcamentioning

confidence: 99%

“…29,30 Recent high-resolution array of comparative genomic hybridization (array-CGH) studies have identified several chromosomal alterations using PCa cell lines and primary tissues. [31][32][33] Among these chromosomal deletion or amplification regions, novel cancer-related genes or miRNA might exist.…”

Section: Chromosome Mapping Of Aberrantly Expressed Mirna In Pcamentioning

confidence: 99%

Functional significance of aberrantly expressed microRNAs in prostate cancer

et al. 2015

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microRNAs, a class of small non-coding RNAs, regulate protein-coding gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. A growing body of evidence suggests that microRNAs contribute to prostate cancer development, progression and metastasis. Based on reports describing microRNA expression signatures, several differentially expressed microRNAs have been discovered. In the present review, eight genome-wide microRNA expression signatures were used to select aberrantly expressed microRNAs (i.e. upregulated and downregulated microRNAs) in prostate cancer clinical specimens. Also, we mapped these selected microRNAs in the human genome. Interestingly, some clustered microRNAs, such as miR-221/222, miR-143/ 145, miR-23b/27b/24-1 and miR-1/133a, are frequently downregulated in cancer tissues, and recent studies have shown that these clustered microRNAs function as tumor suppressors. We also discuss the functional significance of the differentially expressed microRNAs and the molecular pathways/targets regulated by these microRNAs. These recent findings of microRNAs in prostate cancer will facilitate the development of effective strategies for microRNA-based therapeutics for the treatment of prostate cancer.

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Genetic changes in pT2 and pT3 prostate cancer detected by comparative genomic hybridization

Cited by 5 publications

References 37 publications

Genetic Alterations at 13q14 May Correlate with Differences in the Biological Behavior of Prostate Cancer between Japanese and Caucasian Men

Genetic Alterations at 13q14 May Correlate with Differences in the Biological Behavior of Prostate Cancer between Japanese and Caucasian Men

Germline Mutations inHOXB13and Prostate-Cancer Risk

Functional significance of aberrantly expressed microRNAs in prostate cancer

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