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Cited by 71 publications
(121 citation statements)
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References 27 publications
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“…We previously introduced the Sgcg-null allele into 4 distinct genetic backgrounds, finding that the DBA/2J background conferred a more severe muscular dystrophy phenotype than the 129T2/SvEmsJ strain, demonstrating the presence of genetic modifier loci (7). In the present study, we interbred the mice from the two parental backgrounds to generate mice homozygous for the Sgcg-null allele in a mixed genetic background.…”
Section: Introductionmentioning
confidence: 87%
See 3 more Smart Citations
“…We previously introduced the Sgcg-null allele into 4 distinct genetic backgrounds, finding that the DBA/2J background conferred a more severe muscular dystrophy phenotype than the 129T2/SvEmsJ strain, demonstrating the presence of genetic modifier loci (7). In the present study, we interbred the mice from the two parental backgrounds to generate mice homozygous for the Sgcg-null allele in a mixed genetic background.…”
Section: Introductionmentioning
confidence: 87%
“…The phenotypic range was determined using two different measures of the disease progress, membrane permeability and fibrosis. Disruption of the dystrophin glycoprotein complex (DGC) enhances membrane leak and promotes abnormal membrane permeability measured as Evans blue dye content in myofibers in vivo (7). The second assay quantifies the hydroxyproline (HOP) content of muscle as a direct reflection of the degree of fibrosis (7).…”
Section: F 2 Mice Display An Intermediate Phenotype Between the Two Pmentioning
confidence: 99%
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“…The γ-sarcoglycan (Sgcg) mouse model closely mimics the phenotype seen in humans with LGMD2C (7). The severity of disease is highly dependent on genetic background pointing to a role for genetic modifiers (8).…”
mentioning
confidence: 99%