Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients

Abstract

AbstractObjectives: To evaluate the association between the genetic polymorphism of the tumor necrosis factor-alpha (TNF-α) gene and the development of sepsis and septic shock in Thai pediatric patients and to investigate the clinical impacts of TNF-α polymorphisms in this population. Methods:To perform this genetic association study, a prospective analysis of pediatric patients (age < 18 years) with clinical sepsis/ septic shock was conducted. All clinical data were collected by pediatric intensive care expe…