Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature

Diatta, Mamadou; Gadji, Macoura; Tamba, Babacar; Diémé, Marie Jeo; Gassama, Bintou Catherine; Kane, M.; Tine, Soukèye Dia

doi:10.1016/j.adoms.2021.100128

Cited by 1 publication

(2 citation statements)

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“…On evaluating the proliferation index/LI of Ki-67 in most common odontogenic lesions, the highest LI was observed in RC and OKC and the least in DC. LI of RC was the highest and comparable to OKC, which is in concordance with the results of Guler et al 13 This could be attributed to the severity of inflammation due to continuous activation of the cells by microorganisms or their toxins in RC, thereby acting as a stimulator for epithelial proliferation leading to an elevated LI 13,14 . Further, the LI of OKC was higher than DC in the present study.…”

Section: Discussionsupporting

confidence: 92%

“…LI of RC was the highest and comparable to OKC, which is in concordance with the results of Guler et al 13 This could be attributed to the severity of inflammation due to continuous activation of the cells by microorganisms or their toxins in RC, thereby acting as a stimulator for epithelial proliferation leading to an elevated LI. 13,14 Further, the LI of OKC was higher than DC in the present study. This was similar to the findings of Nafarzadeh et al 15 and Guler et al, 13 who reported a lower proliferation activity of DC in comparison with OKC, using Ki-67, PCNA, and Ki-67, MCM2 respectively.…”

Section: Discussioncontrasting

confidence: 39%

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Immunohistochemical Comparison of Ki-67 and MCM-3 in Odontogenic Cysts: An Observational Study

Bhola,

Narwal,

Kamboj

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

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Odontogenic cysts are a diverse group of pathologic entities with different proliferation potential, leading to variations in their biological behavior. One of the most cited proliferation markers used in diagnostic histopathology is Ki-67. Another group of proteins recently investigated is minichromosome maintenance (MCM-3) and its expression has been evaluated in several odontogenic lesions but the results were controversial. Thus, the present study endeavored to compare the expression of MCM-3 and Ki-67 in odontogenic cysts. Furthermore, a pioneer attempt was made to evaluate the sensitivity of these markers to inflammation. A total of 101 cases (37 dentigerous cysts, 37 odontogenic keratocysts, and 27 radicular cysts) were included. Immunohistochemical expression of Ki-67 and MCM-3 were investigated using a labeling index (LI). In addition, they were scored for inflammation, followed by correlation with both markers. The data obtained were subjected to statistical analysis (P<0.05). Overall, a higher LI of MCM-3 than Ki-67 was obtained in all study groups along with a positive correlation of Ki-67 LI with inflammation. Thus, MCM-3 proteins proved to be a more accurate means to determine the proliferation potential and were not sensitive to external stimuli like inflammation than conventional markers, such as Ki-67.

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Section: Discussionsupporting

confidence: 92%