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Cited by 47 publications
(37 citation statements)
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References 47 publications
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“…FXR ‐deficient male mice fed a Western diet had more severe steatohepatitis than female mice . Another study examining the effect of a high‐fat, high‐fructose diet found that male mice had higher hepatic triglyceride levels and developed more severe steatosis compared to female mice for most (but not all) of the more than 100 inbred strains used . Studies with high‐fat diets found more severe liver histologic changes in male than female subjects .…”
Section: Sex Differences In Experimental Nafldmentioning
confidence: 99%
See 1 more Smart Citation
“…FXR ‐deficient male mice fed a Western diet had more severe steatohepatitis than female mice . Another study examining the effect of a high‐fat, high‐fructose diet found that male mice had higher hepatic triglyceride levels and developed more severe steatosis compared to female mice for most (but not all) of the more than 100 inbred strains used . Studies with high‐fat diets found more severe liver histologic changes in male than female subjects .…”
Section: Sex Differences In Experimental Nafldmentioning
confidence: 99%
“…In genome‐wide association studies (GWAS) on NAFLD, sex is generally considered only as a covariate, but sex–gene and gene–sex hormone interactions are neglected despite the fact that both experimental and clinical studies have documented the importance of sex as an effect modifier in gene‐association studies . Immune‐regulating genes on X chromosomes are typically excluded from GWAS owing to their complex regulation.…”
Section: Consideration Of Sex Differences In Nafld Researchmentioning
confidence: 99%
“…The coefficients of variation for Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/20:0) were better than 14, 14, and 10%, respectively. Measurements of total triacylglycerol (TAG) using a colorimetric assay (Sigma-Aldrich, St. Louis, MO) were performed as previously described (11).…”
Section: Murine Liver Lipid Extraction and Quantificationmentioning
confidence: 99%
“…As LeBoeuf highlights, male LDLR−/− mice – particularly on the C57Bl/6 background 73 - are relatively susceptible to diet-induced obesity 73 . Male LDLR−/− mice also develop more severe hypertriglyceridemia 74 and hepatic steatosis when challenged with high fat diets 75 ; whether these differences 7274 are responsible for gender-specific responses to atheroma modulation by PPAR-gamma agonists remains to be determined 74 . The enhanced myeloid adipo-inflammatory response of male mice to high fat diet feeding may be responsible, and these sexually dimorphic metabolic responses have been recently reviewed in detail 76 .…”
Section: Preclinical Models Of Arterial Calcification In the Setmentioning
confidence: 99%