“…Stimulation of vascular endothelial cells and Tcadherin overexpressing HEK293 cells with plasma low density lipoproteins demonstrated the T-cadherin-induced signaling involving phospholipase C and IP3 formation, intracellular Ca 2+ mobilization, activation of tyrosine kinases Erk 1/2, and nuclear translocation of NF-kB (Kipmen-Korgun et al, 2005;Rubina et al, 2005b). However, in contrast to endothelial cells, overexpression of T-cadherin in C6 glioma (Huang et al, 2003) hepatocellular carcinoma cells (Chan et al, 2008), in immortalized keratinocytes (Mukoyama et al, 2005) and in p53(-/-) mouse embryonic fibroblasts (Chan et al, 2008) suppresses proliferation by delaying the G 2 /M phase progression. In hepatocellular carcinoma cells T-cadherin expression also increases sensitivity to TNF-induced apoptosis (Chan et al, 2008).…”