Biochemical Pharmacology volume 78, issue 11, P1401-1411 2009 DOI: 10.1016/j.bcp.2009.07.004 View full text
Jing Ji, Mélanie Bourque, Thérèse Di Paolo, Dean E. Dluzen

Abstract: Female mice with a heterozygous mutation of their dopamine transporter (+/- DAT) showed relatively robust reductions in striatal DAT specific binding (38-50%), while +/- DAT males showed modest reductions (24-32%). Significant decreases in substantia nigra DAT specific binding (42%) and mRNA (24%) were obtained in +/- DAT females, but not +/- DAT males (19% and 5%, respectively). The effects of this DAT perturbation upon vesicular monoamine transporter-2 (VMAT-2) function revealed significantly greater reserpi…

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