Genes That Predict Poor Prognosis in Breast Cancer via Bioinformatical Analysis

Zhou, Qian; Liu, Xiaofeng; Lv, Mingming; Sun, Erhu; Lü, Cheng

doi:10.1155/2021/6649660

Cited by 10 publications

(8 citation statements)

References 26 publications

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“… 33 Some reports have indicated that HMMR is a gene for poor prognosis of BC, and its dysregulation is closely associated with tumor cell phenotype and microenvironment. 34 , 35 In this work, raised HMMR in BC samples and cells was seen, consistent with previous reports. Of note, functional analysis discovered that the overexpression of HMMR might partially alleviate the malignant phenotype of BC cells and the inhibition of glutamine metabolism induced by circ_0005273 deletion.…”

Section: Discussionsupporting

confidence: 92%

“…Existing evidence has revealed that HMMR is often freakishly expressed in human tumors and its overexpression might accelerate the formation and progression of different cancers, such as lung adenocarcinoma 32 and colon cancer 33 . Some reports have indicated that HMMR is a gene for poor prognosis of BC, and its dysregulation is closely associated with tumor cell phenotype and microenvironment 34,35 . In this work, raised HMMR in BC samples and cells was seen, consistent with previous reports.…”

Section: Discussionsupporting

confidence: 91%

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Hsa_circ_0005273 acts as a sponge of miR‐509‐3p to promote the malignant behaviors of breast cancer by regulating HMMR expression

Peng

Cui

et al. 2023

Thoracic Cancer

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Background Breast cancer (BC) is a common malignant tumor that threatens the health of women worldwide. Hsa_circ_0005273 has been identified as a carcinogenic factor in some solid tumors, including BC. However, the molecular mechanism of circ_0005273 in BC is poorly defined. Methods The expression of circ_0005273, miR‐509‐3p, and hyaluronan‐mediated motility receptor (HMMR) mRNA in BC was detected by quantitative real‐time polymerase chain reaction. Cell proliferation, migration, invasion, and apoptosis were detected by 5‐ethynyl‐2′‐deoxyuridine, transwell, and flow cytometry assays. The glycolysis level was detected via specific kits. Western blot was used to detect protein expression. Binding between miR‐509‐3p and circ_0005273 or HMMR was also verified by dual‐luciferase reporter, RNA pull‐down, and RNA immunoprecipitation assays. Xenograft tumor model was used to detect tumor changes in mice, and immunohistochemistry assay was employed to detect Ki‐67 abundance. Results Circ_0005273 was increased in BC tissues and cells. Circ_0005273 knockdown might inhibit BC cell proliferation, migration, invasion, glutamine metabolism, and induce apoptosis. Circ_0005273 was a miR‐509‐3p, and the repression role of circ_0005273 absence on BC cell development was weakened by miR‐509‐3p inhibitor or HMMR overexpression. Circ_0005273 up‐regulated the expression of HMMR by sponging miR‐509‐3p. Additionally, circ_0005273 silencing might hinder tumor growth in vivo . Conclusion Circ_0005273 knockdown might repress BC cell malignant behaviors by regulating the miR‐509‐3p/HMMR axis, which might provide a potential therapeutic target for BC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Hsa_circ_0005273 acts as a sponge of miR‐509‐3p to promote the malignant behaviors of breast cancer by regulating HMMR expression

Peng

Cui

et al. 2023

Thoracic Cancer

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“…These show that elevated RHAMM expression is characteristic of most cancers and prognostic of a poor outcome in many. For example, elevated RHAMM expression is an indicator of poor prognosis in breast cancer [ 119 , 120 , 121 ], multiple myeloma [ 122 ], oral squamous cell carcinoma [ 123 ], ovarian cancer [ 124 ], lung cancer [ 125 ], prostate cancer [ 126 ], colon cancer [ 127 ], and gastric cancer [ 128 ]. However, histology analyses of these human tumors reveal that RHAMM expression is heterogeneous, and high RHAMM expression is often limited to a small subset of cancer cells [ 119 ].…”

Section: Rhamm Multi-functions In Cancermentioning

confidence: 99%

RHAMM Is a Multifunctional Protein That Regulates Cancer Progression

Messam

Tölg

McCarthy³

et al. 2021

IJMS

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The functional complexity of higher organisms is not easily accounted for by the size of their genomes. Rather, complexity appears to be generated by transcriptional, translational, and post-translational mechanisms and tissue organization that produces a context-dependent response of cells to specific stimuli. One property of gene products that likely increases the ability of cells to respond to stimuli with complexity is the multifunctionality of expressed proteins. Receptor for hyaluronan-mediated motility (RHAMM) is an example of a multifunctional protein that controls differential responses of cells in response-to-injury contexts. Here, we trace its evolution into a sensor-transducer of tissue injury signals in higher organisms through the detection of hyaluronan (HA) that accumulates in injured microenvironments. Our goal is to highlight the domain and isoform structures that generate RHAMM’s function complexity and model approaches for targeting its key functions to control cancer progression.

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“…Many genes exhibit differences in expression levels between normal and cancer tissues. In addition, certain genes demonstrate significant changes in expression levels in cancer tissues with a poor prognosis 9 , 10 . It is possible that subsequent treatment could be changed or modified depending on the gene expression pattern in the cancer.…”

Section: Introductionmentioning

confidence: 99%

Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis

Kitamura

Yamamoto

Ochi

et al. 2023

Sci Rep

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Cancer treatment is still challenging because the disease is often caused by multiple mutations. Although genomic studies have identified many oncogenes and tumor suppressor genes, gene sets involved in tumorigenesis remain poorly understood. Xenopus, a genus of aquatic frogs, is a useful model to identify gene sets because it can be genetically and experimentally analyzed. Here, we analyzed gene expression in tumor tissues of three individuals in Xenopus tropicalis and identified 55 differentially expressed genes (DEGs). Gene ontology (GO) analysis showed that the upregulated genes in the tumor tissues were enriched in GO terms related to the extracellular matrix and collagen fibril organization. Hierarchical clustering showed that the gene expression patterns of tumor tissues in X. tropicalis were comparable to those of human connective, soft, and subcutaneous tissue-derived cancers. Additionally, pathway analysis revealed that these DEGs were associated with multiple pathways, including the extracellular matrix, collagen fibril organization, MET signaling, and keratan sulfate. We also found that the expression tendency of some DEGs that have not been well analyzed in the cancer field clearly determines the prognosis of human cancer patients. This study provides a remarkable reference for future experimental work on X. tropicalis to identify gene sets involved in human cancer.

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Genes That Predict Poor Prognosis in Breast Cancer via Bioinformatical Analysis

Cited by 10 publications

References 26 publications

Hsa_circ_0005273 acts as a sponge of miR‐509‐3p to promote the malignant behaviors of breast cancer by regulating HMMR expression

Hsa_circ_0005273 acts as a sponge of miR‐509‐3p to promote the malignant behaviors of breast cancer by regulating HMMR expression

RHAMM Is a Multifunctional Protein That Regulates Cancer Progression

Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis

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