Generalized spiny hyperkeratosis, universal alopecia, and deafness. A previously undescribed syndrome

Keratitis‐ichthyosis‐deafness (KID) syndrome with squamous cell carcinoma

“…Susceptibility to skin infections has been reported in association with KID syndrome and was also observed in this case 4–10,12–14,18,19 . There are also reports of systemic infections and even septicemia leading to death.…”

Auditory Manifestations of Keratitis‐Ichthyosis‐Deafness (KID) Syndrome

“…Table I and the data for our own study subjects demonstrates that the HL in most patients with KID syndrome is primarily sensorineural. Conductive components of the HL in KID syndrome have only been reported twice, 22,23 and we also detected a conductive loss in only one of our study subjects.…”

Deafness, ichthyosiform erythroderma, corneal involvement, photophobia and dental dysplasia

“…Fishman and Christal (1973) reported on a family with congenital ichthyosis and early childhood deafness. Koblenzer (1965) likewise described a boy with congenital ichthyosis and deafness, but Morris et al (1969) and Myers et al (1971) subsequently refuted the earlier report and described the changes in this patient as a new syndrome comprising spinous hyperkeratosis, alopecia and deafness. Haxthausen (1955) mentioned a 5-year-old girl with acanthosis nigricans and congenital deafness who, 13 years later, was again described by as follows: 'One of us saw a deaf 18-year-old girl with congenital acanthosis nigricans, keratosis palmaris et plantaris and extensive ichthyotic changes in the flexural areas and on the face.…”