Generalized pustular psoriasis

Murphy, F. R.

doi:10.1001/archderm.115.10.1215

Cited by 13 publications

(2 citation statements)

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“…Disease onset is typically in the third trimester, although it may occur earlier in pregnancy, and both cutaneous and systemic symptoms resolve gradually following delivery or termination of pregnancy 15, 91, 120–122 . Recurrence may occur with subsequent pregnancy, ovulation or oral contraceptive use, suggesting a role for progesterone in disease precipitation 15, 91, 120, 121, 123, 124 . In addition, von Zumbusch type GPP has been reported in the setting of progesterone challenge 95 .…”

Section: Pustular Psoriasis and Clinical Variantsmentioning

confidence: 99%

Autoinflammatory Pustular Neutrophilic Diseases

Naik

Cowen

2013

Dermatologic Clinics

114

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SYNOPSIS The inflammatory pustular dermatoses constitute a spectrum of non-infectious conditions ranging from localized involvement to generalized disease with associated acute systemic inflammation and multi-organ involvement. Despite the variability in extent and severity of cutaneous presentation, each of these diseases is characterized by non-infectious neutrophilic intra-epidermal microabscesses. Many share systemic findings including fever, elevated inflammatory markers, inflammatory bowel disease and/or osteoarticular involvement, suggesting potential common pathogenic links (Figure 1). The recent discoveries of several genes responsible for heritable pustular diseases have revealed a distinct link between pustular skin disease and regulation of innate immunity. These genetic advances have led to a deeper exploration of common pathways in pustular skin disease and offer the potential for a new era of biologic therapy which targets these shared pathways. This chapter provides a new categorization of inflammatory pustular dermatoses in the context of recent genetic and biologic insights. We will discuss recently-described monogenic diseases with pustular phenotypes, including deficiency of IL-1 receptor antagonist (DIRA), deficiency of the IL-36 receptor antagonist (DITRA), CARD14-associated pustular psoriasis (CAMPS), and pyogenic arthritis, pyoderma gangrenosum, acne (PAPA). We will then discuss how these new genetic advancements may inform how we view previously described pustular diseases, including pustular psoriasis and its clinical variants, with a focus on historical classification by clinical phenotype.

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Section: Pustular Psoriasis and Clinical Variantsmentioning

confidence: 99%

Autoinflammatory Pustular Neutrophilic Diseases

Naik

Cowen

2013

Dermatologic Clinics

114

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“…69 Some state courts, in addition, do not limit intervention to only life-threatening situations but may also act to protect and enhance the quality of a minor's life. 70 The Supreme Court has stated that the power of the state to control the conduct of children reaches beyond the scope of its authority over adults, 71 because the well-being of its children is a subject within the state's constitutional power to regulate. 72 It follows that courts will then allow for the state to override parental religious freedom in order to protect the child's life.…”

Section: Free Exercise Clause and Major Court Casesmentioning

confidence: 99%