Generalized pruritus: a manifestation of iron deficiency

Valsecchi, R.

doi:10.1001/archderm.119.8.630

Cited by 15 publications

(17 citation statements)

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“…Therefore, we speculate that higher activity status and subsequent exposure to UV might predispose to rosacea and concurrently decrease the probability of CI occurrence. Higher haemoglobin concentration might also be associated with lower risk of pruritus; conversely, the role of anaemia in eliciting pruritus is widely acknowledged (50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Itch in Elderly People: A Cross-sectional Study

Reszke

Białynicki‐Birula²,

Lindner³

et al. 2019

Acta Derm Venerol

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SIGNIFICANCE Chronic itch is a frequent problem of complex aetiopatho genesis, especially among elderly patients. This study ex tensively evaluated the prevalence, clinical characteristics and possible associations of chronic itch with systemic co morbidities and pharmacotherapy in a cohort of elderly pa tients hospitalized in a geriatric ward, which, to the best of our knowledge, have rarely been reported in the literature. The results of this study support the role of an interdisci plinary diagnostic and therapeutic approach to elderly pa tients with chronic itch. Ageing is associated with numerous medical afflictions, including dermatological symptoms and diseases. Chronic itch (CI) in elderly people is a frequent symptom of diverse aetiology. This study assessed the prevalence and detailed clinical features of CI among 153 elderly patients hospitalized in the geriatric ward, including associations with comorbidities and pharmacotherapy. CI affected 35.3% of subjects, most commonly due to cutaneous conditions, mixed aetiology and neurological disorders (53.7%, 25.9% and 11.1% of pruritic subjects, respectively). The mean itch intensity assessed with the 4-Item Itch Questionnaire (4IIQ) was 6.6 ± 2.8 points. Viral hepatitis (p = 0.02), higher serum creatinine concentration (p = 0.02) and coexistent purpuric lesions (p = 0.002) were associated with higher 4IIQ scores. In logistic regression analysis CI correlated positively with female sex, atopic dermatitis, immobility, rheumatoid arthritis and ischaemic neurological diseases, while low-molecularweight heparins, antipruritic drugs, allergy, rosacea and higher haemoglobin concentration had the contrary effect. CI is a frequent and interdisciplinary problem among elderly subjects, which requires a holistic clinical approach.

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Section: Discussionmentioning

confidence: 99%

Itch in Elderly People: A Cross-sectional Study

Reszke

Białynicki‐Birula²,

Lindner³

et al. 2019

Acta Derm Venerol

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“…Since the prevalence of IDA in patients with CP is one of greatest disagreements in various studies, we suggest more detailed studies in this regard. The definite mechanism of pruritus is still idiopathic in IDA; the role for the activity of many enzymes, chemical reaction, and epithelial changes could predispose patients with iron deficiency to CP …”

Section: Discussionmentioning

confidence: 99%

Chronic generalized pruritus without primary skin lesions: a longitudinal prospective observational study

et al. 2018

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Pruritus is among the most common complaints in the field of dermatology. It is also a disturbing symptom of many systemic disorders. Chronic pruritus (CP) refers to the cases of the symptom which last longer than 6 weeks. We conducted a prospective analysis of patients with generalized pruritus without primary skin lesions. All patients underwent primary evaluations and then were followed from 12 to 18 months for further evaluations. Of the 5,127 patients referred to our dermatology clinic, 49 patients with generalized pruritus without primary skin lesions were evaluated. Most of the patients (44%) were in the age group of 40-60 years and female (58%). The duration of pruritus was 37.04 ± 30.4 weeks. Fifty percent of the patients with generalized pruritus had a systemic cause of pruritus. The most common underlying diseases were thyroid disorders (16.67%), diabetes mellitus (12.5%), and malignancy (8.33%). There were no significant statistical differences among the patients in terms of their age, gender, and disease duration with the underlying diseases (P = 0.47, P = 0.99, P = 0.816, respectively). However, the average age of the onset of pruritus was 12 years earlier in the women regardless of the underlying diseases (P = 0.011). Based on the findings of the study, we recommend considering endocrine disorders and malignancies as the most common underlying diseases leading to chronic pruritus without primary skin lesions.

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“…In all cases of generalized pruritus without rash (GPWOR), but especially where iron loss is suspected, it is important to enquire about diet (vegetarian or vegan), potential sources of blood loss and gastrointestinal symptoms. Generalized pruritus associated with iron deficiency was first described over 40 years ago . Iron replacement leads in some cases to complete cessation of pruritus very shortly after commencement of therapy …”

Section: Investigation Of Generalized Pruritus Without Rash and Intermentioning

confidence: 99%

“…Generalized pruritus associated with iron deficiency was first described over 40 years ago . Iron replacement leads in some cases to complete cessation of pruritus very shortly after commencement of therapy …”

Section: Investigation Of Generalized Pruritus Without Rash and Intermentioning

confidence: 99%