Generalized paraffinoma (sclerosing lipogranuloma)

Urbach, F.

doi:10.1001/archderm.103.3.277

Cited by 17 publications

(12 citation statements)

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“…Thus, use of petroleum injectables has been abandoned. 3 Ophthalmologists have reported lipogranulomas as a consequence of external dacryocystorhinostomy. In a case report of 4 patients who underwent the surgical procedure, they developed a mass in the incision site that resulted from a reaction to the antibiotic ointment vehicle, which contained petroleum jelly-impregnated gauze placed intranasally.…”

Section: Commentmentioning

confidence: 99%

Foreign-Body Inclusion Cyst Presenting on the Lateral Nasal Sidewall 1 Year After Rhinoplasty

Bassichis

Thomas

2003

Archives of Facial Plastic Surgery

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Section: Commentmentioning

confidence: 99%

Foreign-Body Inclusion Cyst Presenting on the Lateral Nasal Sidewall 1 Year After Rhinoplasty

Bassichis

Thomas

2003

Archives of Facial Plastic Surgery

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“…19 Petrolatum jelly products are composed of saturated hydrocarbons known as n-alcanes that are indigestible by cellular enzymes. 20 Ophthalmic ointments that include white petrolatum, paraffin, and mineral oil can stimulate a foreign body granulomatous reaction when exposed to subconjunctival blood vessels. 6,10,20,21 Heidingsfeld 21 in 1906 first described a foreign body reaction to lipid substances introduced for cosmetic and prosthetic procedures.…”

Section: Discussionmentioning

confidence: 99%

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

Belinsky

Patel²,

Charles³

et al. 2015

Ophthalmic Plastic &Amp; Reconstructive Surgery

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The appearance of eyelid lumps or fullness in the early and mid-postoperative recovery should suggest ointment granuloma. If recognized early, management should commence with intralesional injection of steroids, although the definitive treatment is surgical excision. The authors recommend minimizing the access of topical ointments to the open inferior fornix, placing the medication sparingly onto the cornea at the close of surgery and instructing patients in avoiding overuse.

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“…The first use of mineral oil injection for cosmetic purpose was described by Gersuny in 1899 and involved the scrotal injection of paraffin oil in a young male [1]. Throughout the latter half of the 20th century, various case reports emerged, describing the complications related to local inflammatory reactions from the subcutaneous injection of paraffin oil at various body sites (penis, breast, cheek, eyelids and nose) [2][3][4][5]. Acute pneumonitis from mineral oil embolism has been sporadically reported after the intentional or accidental injection of mineral oil or as a complication of lymphangiography [6].…”

Section: Discussionmentioning

confidence: 99%

A 26-year-old transsexual male with acute respiratory distress and haemoptysis

Blewett

Girod

2005

Breathe

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A 26-year-old male pre-operative transsexual presented to the emergency dept of the University of Texas Southwestern Medical Center (TX, USA) with complaints of acute dyspnoea and frank haemoptysis. The patient did not use intravenous or illicit drugs, alcohol or tobacco, but had a history of unprotected homosexual intercourse. On physical examination, the patient was in severe respiratory distress, with a respiratory rate of 38 breaths per minute and accessory muscle use. The physical examination revealed subcutaneous emphysema, diffuse bilateral crackles, and mediastinal crepitus consistent with a Hamman's crunch. The patient had decreased facial and body hair, moderate breast augmentation and male genitalia. Arterial blood gases on room air revealed a pH 7.43, carbon dioxide tension (PCO 2 ) 4.66 kPa (35 mmHg), arterial oxygen tension (Pa,O 2 ) 4.39 kPa (33 mmHg) and 65% saturation. The patient was placed on a high-flow oxygen mask (non-rebreather mask), and subsequent arterial blood gases showed a pH 7.43, PCO 2 5.05 kPa (38 mmHg), Pa,O 2 7.98 kPa (60 mmHg) and 89% saturation.Laboratory data revealed a haematocrit of 27% (0.27), a normal white blood cell count and an unremarkable coagulation profile. Serum chemistries revealed an elevated lactic dehydrogenase of 252 U·L -1 (normal range 100-190 U·L -1 ). A urinary toxicology screen was negative for cocaine or opiates. The patient was empirically treated for Pneumocystis carinii pneumonia (PCP) and severe community-acquired pneumonia, with intravenous methylprednisolone, trimethoprim/sulphamethoxazole and ticarcillin/clavulanate.Blood, sputum and urine bacterial cultures were negative. Sputum samples were negative for P. carinii by direct fluorescent antibody and stains for acid-fast bacilli (AFB). An HIV antibody test was negative. The CD4 count was 103 cells·mm -3 (normal range 416-1,751 cells·mm -3 ) and HIV viral load was <400 copies·mL -1 (limit of detection <400 copies·mL -1 ). Serial bronchoalveolar lavage (BAL) revealed increasingly bloody returns consistent with diffuse alveolar haemorrhage. The first aliquot contained 465,000 red blood cells·µL -1 and 800 nucleated cells·µL -1 (67% neutrophils, 25% monocytes, 3% lymphocytes, 2% mesothelial cells, 3% eosinophils), while aliquot number four contained 510,000 red blood cells·µL -1 and 300 nucleated cells·µL -1 (77% neutrophils, 15% monocytes, 2% lymphocytes, 3% mesothelial cells, 2% eosinophils). BAL stains were negative for PCP, AFB, and fungal and bacterial pathogens. Serum anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibodies were negative.A computed tomography (CT) scan was performed on the patient and is shown in figure 1. The patient's original BAL fluid was further examined with Sudan stain and an example of this is shown in figure 2.

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Generalized paraffinoma (sclerosing lipogranuloma)

Cited by 17 publications

References 0 publications

Foreign-Body Inclusion Cyst Presenting on the Lateral Nasal Sidewall 1 Year After Rhinoplasty

Foreign-Body Inclusion Cyst Presenting on the Lateral Nasal Sidewall 1 Year After Rhinoplasty

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

A 26-year-old transsexual male with acute respiratory distress and haemoptysis

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