Generalized Nummular Eczema Secondary to Peginterferon Alfa-2b and Ribavirin Combination Therapy for Hepatitis C Infection

Shen, Yang; Pielop, Josie; Hsu, Sylvia

doi:10.1001/archderm.141.1.102-b

Cited by 33 publications

(13 citation statements)

References 8 publications

(7 reference statements)

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“…Peginterferon induces injection site reactions in 36%-59% of cases [14,15] and can sometimes cause generalized dermatitis [13,16,17] . In our study of chronic hepatitis C patients, we only assessed the presence of pruritus and excluded injection site reactions and atopic dermatitis from the analysis.…”

Section: Discussionmentioning

confidence: 99%

Study of pruritus in chronic hepatitis C patients

Suzuki¹,

Tamano²,

Katayama³

et al. 2014

WJG

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AIM:To investigate the occurrence and severity of pruritus in chronic hepatitis C patients treated with or without interferon (IFN) therapy. METHODS:A total of 89 patients with chronic hepatitis C and 55 control (non-hepatitis) patients were asked to rate their experience of diurnal and nocturnal pruritus in the preceding week using a visual analogue scale (VAS) and a five-point scale, respectively. Blood samples were taken and serum thymus and activationregulated chemokine (TARC) levels were measured by enzyme-linked immunosorbent assay. RESULTS:A significantly greater proportion of chronic hepatitis C patients experienced nocturnal pruritus compared with control (58.4% vs 5.5%, P < 0.0001).Chronic hepatitis C patients also had more severe pruritus compared with control patients, indicated by the higher mean VAS scores in both the IFN-treated and non-IFN-treated groups. In particular, patients who received combined peginterferon alfa-2b and ribavirin had significantly higher mean VAS scores than those receiving peginterferon alfa-2a or no IFN treatment. Serum TARC levels did not correlate with pruritus scores, and no significant differences in TARC levels were observed between the IFN-treated and non-IFN-treated groups. CONCLUSION:Patients with chronic hepatitis C experience pruritus more than those without. Serum TARC levels do not correlate with pruritus severity in chronic hepatitis C patients. Key words: Hepatitis C; Pruritus; Peginterferon; Ribavirin; Thymus and activation-regulated chemokine Core tip: This is the first paper to evaluate the occurrence and severity of pruritus in chronic hepatitis C patients and to examine the relationship between pruritus and interferon therapy. We found that patients with chronic hepatitis C experience pruritus more than those without chronic hepatitis C.

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Section: Discussionmentioning

confidence: 99%

Study of pruritus in chronic hepatitis C patients

Suzuki¹,

Tamano²,

Katayama³

et al. 2014

WJG

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“…11Y13 In some patients, nummular eczema has also exceptionally been induced by methyldopa, 14 gold, 15 and peginterferon alfa-2b and ribavirin. 16 Contact irritation and contact sensitivity are uncommonly reported as etiological causes. In particular, anecdotal reports have described nummular eczema as a result of hypersensitivity to aloe, 17 ethylenediamine hydrochloride, 18 depilatory creams, 19 mercury, 20 soluble oils, 21 and scabies treatment.…”

mentioning

confidence: 99%

Nummular Eczema and Contact Allergy

Bonamonte¹,

Foti²,

Vestita³

et al. 2012

Dermatitis

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“…This could be attributable to the complex etiology in chronic eczema. For example, some patients with chronic eczema may be in constant contact or intake of allergic or irritant substances without awareness (Le Coz & Goossens, 1998;Shen, Pielop, & Hsu, 2005) and/or hypersensitive to substances that normally do not induce dermatoses in normal subjects (Schnuch, Brasch, & Uter, 2008). In certain cases, failure to avoid trigger factors of chronic eczema could also contribute to poor outcome of treatments (Proksch & Brasch, 2012).…”

Section: Discussionmentioning

confidence: 99%

The benefit of a ceramide‐linoleic acid‐containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses

Yang

Liu

et al. 2019

Dermatologic Therapy

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Atopic dermatitis (AD), chronic eczema, and pruritus hiemalis are a set of prevalent chronic xerotic skin disorders that share clinical features such as dryness, scales, and pruritus. A ceramide deficiency and defective epidermal functions are common in these diseases. This study was designed to assess the effect of ceramide‐linoleic acid (LA‐Cer)–containing moisturizer as an adjunctive therapy in the treatment of AD, chronic eczema, and pruritus hiemalis. In a 2‐month study, patients with one of these three diseases were divided into two groups. The control group was treated with mometasone furoate (0.1%) cream (MF), whereas the treatment group received 0.1% MF in combination with an LA‐Cer‐containing moisturizer. Capacitance and transepidermal water loss were measured in normal and lesional skin, along with Eczema Assessment Severity Index and pruritus scores at Weeks 0, 2, 4, and 8. The results showed that tropical applications of an LA‐Cer‐containing moisturizer in combination with a topical glucocorticoid accelerated the reestablishment of epidermal permeability barrier and the amelioration of pruritus in patients with AD and pruritus hiemalis. However, it did not provide the same effect for chronic eczema. Thus, the efficacy of this combination therapy for this set of xerotic disorders requires further evaluation.

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Generalized Nummular Eczema Secondary to Peginterferon Alfa-2b and Ribavirin Combination Therapy for Hepatitis C Infection

Cited by 33 publications

References 8 publications

Study of pruritus in chronic hepatitis C patients

Study of pruritus in chronic hepatitis C patients

Nummular Eczema and Contact Allergy

The benefit of a ceramide‐linoleic acid‐containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses

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