Archives of Dermatology
 1972
DOI: 10.1001/archderm.106.4.509
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Generalized morphea. I. Histology of the dermis and subcutaneous tissue

Raúl Fleischmajer1
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Cited by 39 publications

(24 citation statements)
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“…The presence of lymphoid follicles was observed in 45% of our cases, with formation of germinal centers in 18% of them, a frequency similar to that reported by Sanchez and coworkers 19 . However, lymphoid follicles within the subcutaneous fat are not pathognomonic of LEP, as they may be found also in cases of morphea, erythema nodosum, panniculitis associated with dermatomyositis, and erythema induratum of Bazin 29,30 . In this context, we would like to underline that in our experience, lymphoid follicles are never observed in cases of SPTCL 31 .…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The presence of lymphoid follicles was observed in 45% of our cases, with formation of germinal centers in 18% of them, a frequency similar to that reported by Sanchez and coworkers 19 . However, lymphoid follicles within the subcutaneous fat are not pathognomonic of LEP, as they may be found also in cases of morphea, erythema nodosum, panniculitis associated with dermatomyositis, and erythema induratum of Bazin 29,30 . In this context, we would like to underline that in our experience, lymphoid follicles are never observed in cases of SPTCL 31 .…”
Section: Discussionsupporting
confidence: 87%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our results confirm those of Fleischmajer, et al in which 84% of 43 patients with morphea had lymphoplasmacytic infiltrates present both in the dermis and subcutis. 1, 2 We found lymphocytes in 91.2% of our specimens and plasma cells in 74.7% of specimens. The presence of plasma cells in addition to lymphocytes in 75% of specimens is congruent with current theories of the mechanism of fibrosis implicating a Th2 dominated immune response.…”
Section: Discussionmentioning
confidence: 48%
“…20, 21 Skewed activation of the adaptive immune response producing a Th2 dominant pattern of cytokine release is thought to be a key mediator of fibrosis and is associated with antibody production by plasma cells. Although prior studies 2 implicate a stepwise progression from inflammatory to sclerotic phases in morphea, inflammation and sclerosis were simultaneously present in this series. This implies that some patients with morphea have ongoing inflammation driving prolonged periods of sclerosis.…”
Section: Discussionmentioning
confidence: 52%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Mucin was also found increased in the area of hyalinization in 5 of 10 patients with PSS [5]. Later, a positive staining with Alcian blue was found in 1 of 5 cases of generalized morphea [6].…”
Section: Resultsmentioning
confidence: 80%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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