Generalized lichen amyloidosis associated with chronic lichen planus

The Association of Rheumatoid Arthritis with Lichen Amyloidosis: Case Report

“…10,11,15 However, as distinct from those conditions, the patient described here manifested both LA and RA. We speculate that, in the present case theoretically, deregulated immune response leading to progressive synovial inflammation and joint destruction in RA may also allow the degeneration of keratinocytes to be processed into amyloid filaments later.…”

“…[8][9][10] Although the precise cause of LA is uncertain, chronic irritation to the skin resulting in excessive production of degenerate keratins, and their subsequent conversion into amyloid deposits, has been proposed to be an etiologic factor. 11,12 It is stated that any damage to keratinocyte, beyond the ability of the phagocytic cell to remove the abnormal keratins, can be able to cause amyloid deposits. 11 As LA is typically highly pruritic, the chronic irritation to the skin has generally been considered to be secondary to scratching induced by other subjacent pruritogenic processes.…”

“…11,12 It is stated that any damage to keratinocyte, beyond the ability of the phagocytic cell to remove the abnormal keratins, can be able to cause amyloid deposits. 11 As LA is typically highly pruritic, the chronic irritation to the skin has generally been considered to be secondary to scratching induced by other subjacent pruritogenic processes. 8,9 Yet, as it was the case in our patient, mildly or non-pruritic cases have also been described.…”

“…9,14 The diagnosis of LA depends on the clinical and histopathological findings. [8][9][10][11] Lesional skin biopsy generally reveals hyperkeratosis, acanthosis, and focal amyloid deposits within the papillary dermis. [8][9][10] In our patient, although the clinical presentation with hyperpigmented and hyperker- atotic scaly plaques was not so typical for LA, the histopathological examination provided the definitive diagnosis.…”

A clinicopathological study of primary localised cutaneous amyloidosis

“…Lichen amyloidosis has been reported in connection with several skin disorders, including atopic dermatitis, lichen planus, and mycosis fungoides. [17][18][19] The concomitance with polymorphous light eruption suggests that sunlight could be incriminated as a risk factor in the causation of PLCA in our patients. Eswara moorthy et al and Rasi et al, however, did not find any correlation between sun exposure and MA in their studies.…”