Generalized Erythematous Plaques

Progressive symmetric erythrokeratodermia with delayed intellectual milestones and convulsions

“…Orthokeratosis, orthohyperkeratosis with focal parakeratosis, a well-preserved granular layer, psoriasiform hyperplasia without thinned suprapapillary plates, and a perivascular infiltrate of lymphocytes in the upper part of the dermis, have all been reported. [1–4] Associated neurological abnormalities, including deafness, have been described rarely, as seen in this case. [5]…”