Generalized eruptive histiocytoma of childhood

Jang, Kyoung‐Ae; Lee, H J; Choi, Jee‐Ho; Sung, Kyung Jeh; Koh, Jai‐Kyoung; Moon, Kee‐Chan

doi:10.1046/j.1365-2133.1999.02634.x

Cited by 33 publications

(27 citation statements)

References 8 publications

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“…Jang et al . also reported a case of childhood GEH with rapid progression and resolution similar to that of our case 3 . Interestingly, both of the cases had the common electron microscopic finding of intracytoplasmic eyeball‐like lysosomal structures.…”

supporting

confidence: 84%

Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum

Tamiya¹,

Tsuruta²,

Takeda³

et al. 2005

Clin Exp Dermatol

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supporting

confidence: 84%

Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum

Tamiya¹,

Tsuruta²,

Takeda³

et al. 2005

Clin Exp Dermatol

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“…[4] In fact, Jang et al [18] proposed that GEH be divided into the following two subsets: an indifferent stage of other histiocytic disorders and a specific condition without subsequent disorder. [18] Hence, a frequent follow-up of patients is to be done to look for any change in lesions or systemic involvement and if present, it necessitates a repeat biopsy from newer lesion and systemic review. [6] According to a review, PNH has been considered as the last stage of particular forms of non-langerhans cell histiocytoses such as GEH, xanthoma disseminatum, papular xanthoma, and multicentric reticulohistiocytosis.…”

Section: Discussionmentioning

confidence: 99%

Generalized eruptive histiocytosis mimicking leprosy

Kumar¹,

Nandini²,

Niveditha³

et al. 2011

Indian J Dermatol Venereol Leprol

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Generalized eruptive histiocytosis (GEH) is a rare cutaneous histiocytosis that mainly affects adults and presents with multiple symmetric papules on face, trunk, and proximal extremities. GEH is included in type IIa (histiocytes involving cells of dermal dendrocyte lineage) of histiocytic disorders. Clinical and pathological correlations are required for differentiating GEH from other histiocytic disorders and from lepromatous leprosy which clinically mimic GEH and is prevalent in India. We report a case of a middle-aged woman who presented with generalized asymptomatic papules and nodules and was treated for leprosy but was finally diagnosed to have GEH after clinical, histopathological, and immunohistochemical correlation. Furthermore, the newer lesions also showed features of progressive nodular histiocytosis.

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“…Time to resolution varies from 1–2 months to several years 1,3 . The condition is more common in adults, but cases in children have been described 3,4 …”

Section: Discussionmentioning

confidence: 99%

Papular eruption in an elderly woman

Konstantopoulou¹,

Oliver²,

Lord

et al. 2009

Clinical and Experimental Dermatology

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An 80-year-old woman presented with a 9-week history of multiple nonpruritic, red, shiny, dome-shaped lesions mainly affecting the arms and thighs (Fig. 1). A few lesions were present on the lower back and a single one on the scalp. The patientÕs medical history included hypertension, diabetes, appendicectomy, incisional hernia, cataracts, and myopic degeneration in both eyes. erythrocyte sedimentation rate was moderately raised at 41 mm ⁄ h, but apart from a slightly elevated alkaline phosphatase result, all other investigations were normal. Histopathological findingsSkin biopsy of one of the papular lesions showed a normal epidermis; the dermis contained an infiltrate of macrophages with abundant eosinophilic cytoplasm and large monomorphic oval nuclei. These cells showed immunopositivity for factor XIIIa and CD68, but were negative for S100. Scattered lymphocytes and occasional plasma cells were also seen (Fig. 2a-c).What is your diagnosis? C P D Figure 1 Multiple erythematous, shiny, dome-shaped skin lesions on the thigh.

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Generalized eruptive histiocytoma of childhood

Cited by 33 publications

References 8 publications

Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum

Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum

Generalized eruptive histiocytosis mimicking leprosy

Papular eruption in an elderly woman

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