Generalized argyria in two chronic hemodialysis patients

Sue, Yuh Mou; Lee, J. Yu-Yun; Wang, Ming Cheng; Lin, Tzu Kai; Sung, Junne Ming; Huang, Jing

doi:10.1016/s0272-6386(05)80023-x

Cited by 32 publications

(20 citation statements)

References 11 publications

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“…Many of the industrial silver compounds, including nitrate, chloride, bromide, acetate, oxide, sulfate, and cyanide, 3 can be released in to the environment from various sources. 4 Silver can be found in low levels in many tissues, [4][5][6][7] but without any clear physiologic function. Dermal exposure to high doses of silver causes argyria and mild allergic responses.…”

Section: Introductionmentioning

confidence: 99%

Acute and subchronic dermal toxicity of nanosilver in guinea pig

Korani

Rezayat²,

Gilani³

et al. 2011

IJN

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Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this study, we analyzed the potential toxicity of colloidal nanosilver in acute and subchronic guinea pigs. Before toxicity assessments, the size of colloidal nanosilver was recorded in sizes <100 nm by X-ray diffraction and transmission electron microscopy. For toxicological assessments, male guinea pigs weighing 350 to 400 g were exposed to two different concentrations of nanosilver (1000 and 10,000 μg/mL) in an acute study and three concentrations of nanosilver (100, 1000, and 10,000 μg/mL) in a subchronic study. Toxic responses were assessed by clinical and histopathologic parameters. In all experimental animals the sites of exposure were scored for any type of dermal toxicity and compared with negative control and positive control groups. In autopsy studies during the acute test, no significant changes in organ weight or major macroscopic changes were detected, but dose-dependent histopathologic abnormalities were seen in skin, liver, and spleen of all test groups. In addition, experimental animals subjected to subchronic tests showed greater tissue abnormalities than the subjects of acute tests. It seems that colloidal nanosilver has the potential to provide target organ toxicities in a dose- and time-dependent manner.

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Section: Introductionmentioning

confidence: 99%

Acute and subchronic dermal toxicity of nanosilver in guinea pig

Korani

Rezayat²,

Gilani³

et al. 2011

IJN

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“…[67,68] Contaminated water used in hemodialysis has led to generalized argyria. [69] Clinical features In general, the macular pigmentation in argyria is slate -grey. It arises insidiously and is asymptomatic.…”

Section: Discussion Discussionmentioning

confidence: 99%

Granulomatous cheilitis with granulomatous vulvitis: A rare association

Kambil¹,

Bhat²,

Sukumar³

et al. 2013

Indian J Dermatol Venereol Leprol

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Granulomatous cheilitis and granulomatous vulvitis are rare disorders characterized by painless swelling of lips and vulva, respectively. Histopathology of both conditions show non-caseating epithelioid cell granulomas in the dermis. Both disorders have been associated with Crohn's disease rarely. Occurrence of the two conditions in the same patient is extremely infrequent. We hereby report, the association of granulomatous cheilitis with granulomatous vulvitis in a 30-year-old female.

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“…Silver can accumulate in the skin, liver, kidney, corneas, gingival, mucous membranes, nails, and spleen. 1,3,4 Dietl reported that in autopsy findings of manic depressive psychosis patient's, silver deposits were found in the skin, mucous membranes, heart, kidney, liver, and the walls of many intraparenchymal vessels, particularly of the basal ganglia, hypothalamus, substantia nigra, and cerebellum. 5 We found that fine silver granules were deposited in the basement membrane of colon mucosa in the first case (Fig.…”

Section: Discussionmentioning

confidence: 99%