Gene Transfer of Antisense B7.1 Attenuates Acute Rejection Against Liver Allografts in Rats

Abstract

Blocking expression of B7.1 in liver by antisense gene therapy may represent a potential strategy to attenuate acute rejection against liver allografts.

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

“…Therefore, additional Foxp3 assessment was necessary to exclude the involvement of regulatory T cells. CD28 is a co-stimulatory molecule, which is essential for priming T cell activation [15,35]. CD38 was also previously reported as an activation marker of T cell or CD8þ T cells [36,37].…”