Gene Therapy as an Emerging Therapeutic Approach to Breast Cancer: New Developments and Challenges

Sheikh-Hosseini, Motahareh; Larijani, Bagher; Kakroodi, Zahra Gholipoor; Shokoohi, Mahshid; Moarefzadeh, Mohammad; Sayahpour, Forough Azam; Goodarzi, Parisa; Arjmand, Babak

doi:10.1089/hum.2020.199

Cited by 6 publications

(7 citation statements)

References 113 publications

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“…Various strategies have been developed to transfer genetic materials into cancer cells, including viral and non‐viral vectors. Currently, gene therapy using viral and non‐viral vectors to treat different types of tumours, including BC, has entered the clinical trial phase 16,17 . As mentioned above, since breast cancer is one of the most deadly malignancies in women and traditional methods have limitations, the aim of this study was to introduce gene therapy as an effective and promising therapeutic approach for this type of cancer.…”

Section: Introductionmentioning

confidence: 99%

Gene therapy: A promising approach for breast cancer treatment

Dastjerd

Valibeik

Monfared

et al. 2021

Cell Biochemistry & Function

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Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death among women worldwide that is caused by numerous genetic and environmental factors. Hence, effective treatment for this type of cancer requires new therapeutic approaches. The traditional methods for treating this cancer have side effects, therefore so much research have been performed in last decade to find new methods to alleviate these problems. The study of the molecular basis of breast cancer has led to the introduction of gene therapy as an effective therapeutic approach for this cancer. Gene therapy involves sending genetic material through a vector into target cells, which is followed by a correction, addition, or suppression of the gene. In this technique, it is necessary to target tumour cells without affecting normal cells. In addition, clinical trial studies have shown that this approach is less toxic than traditional therapies. This study will review various aspects of breast cancer, gene therapy strategies, limitations, challenges and recent studies in this area.

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Section: Introductionmentioning

confidence: 99%

Gene therapy: A promising approach for breast cancer treatment

Dastjerd

Valibeik

Monfared

et al. 2021

Cell Biochemistry & Function

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“…Conversely, different factors related to an individual's lifestyle such as diet, obesity, and some viral infections or environmental agents like exposure to chemicals and hazardous radiations can be classified as exogenous risk factors (Wu et al, 2018). All of these categories and more on can play a key role in initiation of carcinogenesis multistep process by occurrence of genetic mutations and epigenetic alterations (Belizário, 2018;Sheikh-Hosseini et al, 2021). In other words, the epigenome and the genome can have mutual interaction in the onset of cancer.…”

Section: An Overview Of Cancermentioning

confidence: 99%

Machine Learning: A New Prospect in Multi-Omics Data Analysis of Cancer

et al. 2022

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Cancer is defined as a large group of diseases that is associated with abnormal cell growth, uncontrollable cell division, and may tend to impinge on other tissues of the body by different mechanisms through metastasis. What makes cancer so important is that the cancer incidence rate is growing worldwide which can have major health, economic, and even social impacts on both patients and the governments. Thereby, the early cancer prognosis, diagnosis, and treatment can play a crucial role at the front line of combating cancer. The onset and progression of cancer can occur under the influence of complicated mechanisms and some alterations in the level of genome, proteome, transcriptome, metabolome etc. Consequently, the advent of omics science and its broad research branches (such as genomics, proteomics, transcriptomics, metabolomics, and so forth) as revolutionary biological approaches have opened new doors to the comprehensive perception of the cancer landscape. Due to the complexities of the formation and development of cancer, the study of mechanisms underlying cancer has gone beyond just one field of the omics arena. Therefore, making a connection between the resultant data from different branches of omics science and examining them in a multi-omics field can pave the way for facilitating the discovery of novel prognostic, diagnostic, and therapeutic approaches. As the volume and complexity of data from the omics studies in cancer are increasing dramatically, the use of leading-edge technologies such as machine learning can have a promising role in the assessments of cancer research resultant data. Machine learning is categorized as a subset of artificial intelligence which aims to data parsing, classification, and data pattern identification by applying statistical methods and algorithms. This acquired knowledge subsequently allows computers to learn and improve accurate predictions through experiences from data processing. In this context, the application of machine learning, as a novel computational technology offers new opportunities for achieving in-depth knowledge of cancer by analysis of resultant data from multi-omics studies. Therefore, it can be concluded that the use of artificial intelligence technologies such as machine learning can have revolutionary roles in the fight against cancer.

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“…For example, in the article by Anusha S. Shankar et al, the renin was produced by the use of kidney organoids that were differentiated from induced pluripotent stem cells (iPSCs) [ 24 , 25 ]. Furthermore, organoid technology may be used in the field of organ transplantation by producing the desired organ [ 11 , 16 , 26 ]. Also, organoids derived from patient-derived iPSCs or other cells have been used to test gene therapy [ 11 , 16 , 26 ].…”

Section: Organoids: a Novel Insight To Regenerative Medicinementioning

confidence: 99%

“…Furthermore, organoid technology may be used in the field of organ transplantation by producing the desired organ [ 11 , 16 , 26 ]. Also, organoids derived from patient-derived iPSCs or other cells have been used to test gene therapy [ 11 , 16 , 26 ]. Identifying the wide utilization of organoids from drug mechanisms and enzyme deficiencies to gene therapy and organ transplantation, we find that their emergence is a new innovation in biotechnology with a significant history.…”

Section: Organoids: a Novel Insight To Regenerative Medicinementioning

confidence: 99%

Advancement of Organoid Technology in Regenerative Medicine

Arjmand

Rabbani

Soveyzi

et al. 2022

Regen. Eng. Transl. Med.

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Purpose Organoids are three-dimensional cultures of stem cells in an environment similar to the body’s extracellular matrix. This is also a novel development in the realm of regenerative medicine. Stem cells can begin to develop into 3D structures by modifying signaling pathways. To form organoids, stem cells are transplanted into the extracellular matrix. Organoids have provided the required technologies to reproduce human tissues. As a result, it might be used in place of animal models in scientific study. The key goals of these investigations are research into viral and genetic illnesses, malignancies, and extracellular vesicles, pharmaceutical discovery, and organ transplantation. Organoids can help pave the road for precision medicine through genetic editing, pharmaceutical development, and cell therapy. Methods PubMed, Google Scholar, and Scopus were used to search for all relevant papers written in English (1907–2021). The study abstracts were scrutinized. Studies on the use of stem-cell-derived organoids in regenerative medicine, organoids as 3D culture models for EVs analysis, and organoids for precision medicine were included. Articles with other irrelevant aims, meetings, letters, commentaries, congress and conference abstracts, and articles with no available full texts were excluded. Results According to the included studies, organoids have various origins, types, and applications in regenerative and precision medicine, as well as an important role in studying extracellular vesicles. Conclusion Organoids are considered a bridge that connects preclinical studies to clinical ones. However, the lack of a standardized protocol and other barriers addressed in this review, hinder the vast use of this technology. Lay Summary Organoids are 3D stem cell propagations in biological or synthetic scaffolds that mimic ECM to allow intercellular or matrix-cellular crosstalk. Because these structures are similar to organs in the body, they can be used as research models. Organoids are medicine’s future hope for organ transplantation, tumor biobank formation, and the development of precision medicine. Organoid models can be used to study cell-to-cell interactions as well as effective factors like inflammation and aging. Bioengineering technologies are also used to define the size, shape, and composition of organoids before transforming them into precise structures. Finally, the importance of organoid applications in regenerative medicine has opened a new window for a better understanding of biological research, as discussed in this study.

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Gene Therapy as an Emerging Therapeutic Approach to Breast Cancer: New Developments and Challenges

Cited by 6 publications

References 113 publications

Gene therapy: A promising approach for breast cancer treatment

Gene therapy: A promising approach for breast cancer treatment

Machine Learning: A New Prospect in Multi-Omics Data Analysis of Cancer

Advancement of Organoid Technology in Regenerative Medicine

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