volume 27, issue 4, P809-817 2011
DOI: 10.3233/jad-2011-110755
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Federico Licastro, Ilaria Carbone, Manuela Ianni, Elisa Porcellini

Abstract: Genome wide association investigations from large cohorts of patients with Alzheimer's disease (AD) and non demented controls (CTR) showed that a limited set of genes were associated (p > 10-5) with the disease. A very recent study from our group showed that an additional limited group of SNP in selected genes were associated with AD. In this report we argue that the association of these genes with AD is suggestive of a pivotal role of environmental factors in the pathogenesis of the disease and one of these f…

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