1993
DOI: 10.1001/archderm.129.11.1484
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Gene rearrangements and T-cell lymphomas

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Cited by 9 publications
(6 citation statements)
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“…Some examples include benign inflammatory disorders of skin, such as lymphomatoid papulosis and pityriasis lichenoides et varioliformis acuta, where clonal T cell expansions are evident. [91][92][93] Conversely, the absence of a clonal gene rearrangement does not rule out malignancy because the population of malignant cells may be at a level below the sensitivity of the technique. The current consensus view is that lymphomas can only be defined by a combination of clinical, histological, and immunological data.…”
Section: The Diagnostic Role Of Tcr Gene Rearrangement Studies T Cellmentioning
confidence: 99%
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“…Some examples include benign inflammatory disorders of skin, such as lymphomatoid papulosis and pityriasis lichenoides et varioliformis acuta, where clonal T cell expansions are evident. [91][92][93] Conversely, the absence of a clonal gene rearrangement does not rule out malignancy because the population of malignant cells may be at a level below the sensitivity of the technique. The current consensus view is that lymphomas can only be defined by a combination of clinical, histological, and immunological data.…”
Section: The Diagnostic Role Of Tcr Gene Rearrangement Studies T Cellmentioning
confidence: 99%
“…TCR and clonality studies have proved to be of immense help in the diagnosis and follow up of patients with cutaneous T cell lymphomas. 91 The interpretation of clonality in PTCL can also be difficult, especially those of the angioimmunoblastic type (AILD), where the interpretation of clonality is complicated by the heterogeneity of TCR and IgH rearrangements. In addition, clonal rearrangements have been shown to regress or appear during the course of disease, suggesting that these cases harbour multiple clones similar to those found in cases with acquired immunosuppression.…”
Section: The Diagnostic Role Of Tcr Gene Rearrangement Studies T Cellmentioning
confidence: 99%
“…False positive results can be due to underlying biological as well as technical factors. On one hand, minor T cell clones are detectable in reactive conditions such as autoimmune diseases or viral infections [18,28,29]. In addition, the presence of a monoclonal T cell population could be due to a clinically and morphologically undetectable (pre-) neoplastic disorder, such as, an early stage of T cell large granular lymphocytic leukemia in bone marrow biopsies.…”
Section: Discussionmentioning
confidence: 99%
“…[ 47 48 49 ] TCR-PCR is useful to differentiate the clonal versus polyclonal nature of a T-cell infiltrate. [ 50 51 52 53 54 55 ] However, in early MF, the relative mixture of neoplastic and reactive lymphocytes may yield false-negative results. Conversely, inflammatory dermatoses may demonstrate clonal rearrangements, particularly when performing PCR on sparse infiltrates (oligoclonality), and some inflammatory dermatoses are often clonal albeit exhibiting a benign clinical course (i.e., pityriasis lichenoides [PL], PPPD, medication reactions).…”
Section: Diagnostic Approach Based On the Predominant Morphologic Andmentioning
confidence: 99%