Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease

Jun, Ma; Liew, Choong‐Chin

doi:10.1016/s0022-2828(03)00179-2

Cited by 83 publications

(51 citation statements)

References 18 publications

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“…A gene profile study of peripheral blood cells from patients with coronary artery disease demonstrated a 2.1-fold increase in factor XIII A subunit expression compared with healthy controls (118). Consistent with this observation, a case control study of patients with established CAD showed higher factor XIII A subunit levels compared with control, but there was no association between FXIII A subunit and MI (119).…”

Section: Association Between Factor XIII Levels Cardiovascular Risk mentioning

confidence: 85%

Roles of transglutaminases in cardiac and vascular diseases

Sane

Kontos²,

Greenberg³

2007

Front Biosci

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All transglutaminases share the common enzymatic activity of transamidation, or the cross-linking of glutamine and lysine residues to form N epsilon (gamma-glutamyl) lysyl isopeptide bonds. The plasma proenzyme factor XIII is responsible for stabilizing the fibrin clot against physical and fibrinolytic disruption. Another member of the transglutaminase family, tissue transglutaminase or TG2 is abundantly expressed in cardiomyocytes, vascular cells and macrophages. The transglutaminases have a variety of functions independent of their transamidating activity. For example, TG2 binds and hydrolyzes GTP, thereby fostering signal transduction by several G protein coupled receptors. Accumulating evidence points to novel roles for factor XIII and TG2 in cardiovascular biology including: (a) modulating platelet activity, (b) regulating glucose control, (c) contributing to the development of hypertension, (d) influencing the progression of atherosclerosis, (e) regulating vascular permeability and angiogenesis (f) and contributing to myocardial signaling, contractile activity and ischemia/reperfusion injury. In this review, we summarize the cardiovascular biology of two members of the family of transglutaminases, Factor XIII and TG2.

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Section: Association Between Factor XIII Levels Cardiovascular Risk mentioning

confidence: 85%

Roles of transglutaminases in cardiac and vascular diseases

Sane

Kontos²,

Greenberg³

2007

Front Biosci

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“…Compared with cartilage, peripheral blood is easier to collect and results in reduced wounding. In addition, peripheral blood may respond to rapidly to changes in disease status (8). Therefore, differentially expressed genes in the peripheral blood may be useful results for improving the early diagnosis of KBD.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have analyzed the differentially expressed genes of peripheral blood to identify marker genes for early diagnosis of diseases including cancer, coronary disease and OA (8)(9)(10)(11)(12). With regard to KBD, in prior studies differentially expressed genes in cartilage and peripheral blood have been screened using microarrays (1,7,13).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis

Ning

Wang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the early diagnostic biomarkers of Kashin-Beck disease (KBD), and to compare the common signaling pathways of peripheral mononuclear cells between patients with KBD and those with osteoarthritis (OA). A total of 20 and 12 peripheral blood samples were separately collected from KBD patients and normal control subjects, respectively, in an endemic area according to the diagnosis criteria. Total RNAs were extracted and gene expression levels were determined using an Agilent whole genome expression microarrays. The gene expression data of OA were obtained from GEO published database. Significant different pathways between KBD and OA were analyzed using Ingenuity Pathway Analysis software. A total of 82 differentially expressed genes, 51 significant different signaling pathways and five significant biological functions were identified in KBD patient samples, while 89, 50 and five significantly different genes, pathways and functions were identified in OA. Nine common significant pathways and five common differentially expressed genes were identified between the KBD and OA. Nine common significant pathways and five common differentially expressed genes were found between the two diseases. The present results suggest that there are similarities in vascular microcirculation, immunoreactions and cell apoptosis between KBD and OA, which may contribute to the early diagnosis and pathogenetic study of KBD.

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“…Moreover, genes involved with fatty acid metabolism and electron transport chain showed positive correlation with lowdensity lipoprotein (LDL) levels and negative correlation with high-density lipoprotein (HDL) levels. Finally, platelet activation genes (PF4 and PPBP), which the team had earlier shown up regulated with CAD (Ma and Liew 2003), demonstrated inverse correlation with HDL levels. Although the diagnostic or predictive accuracy of this approach was not determined in this investigation, this work does provide a framework for doing so in future investigations.…”

Section: Hyperlipidemiamentioning

confidence: 81%

Peripheral blood gene expression profiling for cardiovascular disease assessment

Aziz

Zaas

Ginsburg

2007

HUGO J

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Whole blood gene expression profiling has the potential to be informative about dynamic changes in disease states and to provide information on underlying disease mechanisms. Having demonstrated proof of concept in animal models, a number of studies have now tried to tackle the complexity of cardiovascular disease in human hosts to develop better diagnostic and prognostic indicators. These studies show that genomic signatures are capable of classifying patients with cardiovascular diseases into finer categories based on the molecular architecture of a patient's disease and more accurately predict the likelihood of a cardiovascular event than current techniques. To highlight the spectrum of potential applications of whole blood gene expression profiling approach in cardiovascular science, we have chosen to review the findings in a number of complex cardiovascular diseases such as atherosclerosis, hypertension and myocardial infarction as well as thromboembolism, aortic aneurysm, and heart transplant.

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Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease

Cited by 83 publications

References 18 publications

Roles of transglutaminases in cardiac and vascular diseases

Roles of transglutaminases in cardiac and vascular diseases

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis

Peripheral blood gene expression profiling for cardiovascular disease assessment

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