Gene expression profiling in practitioners of Sudarshan Kriya

Sharma, Himani; Datta, Palika; Singh, Archna; Sen, Sayan; Bhardwaj, Narendra Kumar; Kochupillai, V.; Singh, Neeta

doi:10.1016/j.jpsychores.2007.07.003

Cited by 75 publications

(68 citation statements)

References 13 publications

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“…Cutaneous microcirculatory function is higher during practice in tai chi practitioners than in their sedentary counterparts, and this may be mediated by enhanced nitric oxide release (30), a potent vaso-relaxant that can also induce the synthesis of the antioxidant glutathione via an increase in the expression of the catalytic subunit of glutamate cysteine ligase (31). Moreover, it has also been shown that the rhythm of breathing, slow and deep, is associated with a significant increase in the gene expression of glutathione s-transferase (32). A plausible explanation is that both a release of nitric oxide and the slow and deep rhythmic breathing during tai chi improve gPx activity in tai chi practitioners and consequently reinforce endogenous antioxidant potential.…”

Section: Discussionmentioning

confidence: 99%

Dietary intakes and antioxidant status in mind-body exercising pre- and postmenopausal women

Palasuwan

Margaritis

Soogarun

et al. 2011

The Journal of nutrition, health and aging

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Section: Discussionmentioning

confidence: 99%

Dietary intakes and antioxidant status in mind-body exercising pre- and postmenopausal women

Palasuwan

Margaritis

Soogarun

et al. 2011

The Journal of nutrition, health and aging

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“…Similarly, experiments have shown both mindfulness and compassion-focused meditation to be effective in reducing anxiety, depression, and anger while enhancing emotion regulation, empathy, and psychological well-being (e.g., Eberth and Sedlmeier 2012;Hofmann et al 2011). These changes have been linked to changes in gene expression (e.g., Kaliman et al 2014;Sharma et al 2008) and in brain function and structure (Hofmann et al 2011;Hölzel et al 2011).…”

Section: Anomalies That Challenged the Old View Of The Brainmentioning

confidence: 99%

Invited Address: “The Times They Are A-Changin’” Gene Expression, Neuroplasticity, and Developmental Research

Simons

Klopack

2014

J Youth Adolescence

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For good reason, social scientists have a long history of being suspicious of biological explanations of human behavior. Importantly, however, recent paradigmatic shifts in the life sciences have largely obviated these longstanding concerns. We highlight the changes that have occurred in genetics with its movement away from genetic determinism to an emphasis on epigenetics and in neuroscience with its switch from a fixed to a neuroplastic view of the brain. We describe these new developments noting the way they recognize, indeed place a premium upon, the role of the environment. The remainder of the paper focuses upon the challenges and opportunities for social scientists, especially those involved in developmental work, proffered by these paradigmatic shifts. The evidence clearly shows that nature and nurture are inextricably interlinked. Importantly, however, it also indicates that they are connected in a manner that honors the priority that the social sciences place upon the environment. We contend that incorporating biological processes into our developmental work will sharpen our theories and enhance their significance. We argue that such biologically integrated models will provide a clearer and more comprehensive understanding of how nurture influences behavior across the life course.

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“…In particular, mindfulness-based stress reduction (which includes gentle yoga postures), as well as yogic meditation, have recently been shown to reduce inflammatory signaling through the pro-inflammatory NF-κB control pathway (Creswell et al, 2012; Black et al, 2013). However, the few studies to assess gene expression profiles in experienced yoga practitioners did not report effects on inflammation-related genes (Sharma et al, 2008; Qu et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial

Bower¹,

Greendale²,

Crosswell³

et al. 2014

Psychoneuroendocrinology

229

231

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Background Yoga is a popular mind-body therapy that has demonstrated beneficial effects on psychological, behavioral, and functional outcomes. However, few studies have investigated effects on inflammatory processes. This study tested the hypothesis that an Iyengar yoga intervention specifically designed for fatigued breast cancer survivors would lead to decreases in inflammation-related gene expression and circulating markers of proinflammatory cytokine activity. Methods Breast cancer survivors with persistent cancer-related fatigue were randomized to a 12-week Iyengar yoga intervention (n = 16) or a 12-week health education control condition (n = 15). Blood samples were collected at baseline, post-intervention, and at a 3-month follow-up for genome-wide transcriptional profiling and bioinformatic analyses. Plasma inflammatory markers and salivary cortisol were also assessed. Results In promoter-based bioinformatics analyses, the yoga group showed reduced activity of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB), increased activity of the anti-inflammatory glucocorticoid receptor, and reduced activity of cAMP response element-binding protein (CREB) family transcription factors relative to controls (all ps < .05). There was also a significant intervention effect on the soluble tumor necrosis factor receptor type II (sTNF-RII), a marker of TNF activity; plasma levels of sTNF-RII remained stable in the yoga group, whereas levels of this marker increased in the health education group (p = .028). A similar, non-significant trend was observed for the interleukin 1 receptor antagonist (p = .16). No significant changes in C reactive protein (CRP), interleukin 6 (IL-6), or diurnal cortisol measures were observed. Conclusions A 12-week restorative Iyengar yoga intervention reduced inflammation-related gene expression in breast cancer survivors with persistent fatigue. These findings suggest that a targeted yoga program may have beneficial effects on inflammatory activity in this patient population, with potential relevance for behavioral and physical health. ClinicalTrials.gov identifier: NCT00727662.

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Gene expression profiling in practitioners of Sudarshan Kriya

Cited by 75 publications

References 13 publications

Dietary intakes and antioxidant status in mind-body exercising pre- and postmenopausal women

Dietary intakes and antioxidant status in mind-body exercising pre- and postmenopausal women

Invited Address: “The Times They Are A-Changin’” Gene Expression, Neuroplasticity, and Developmental Research

Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial

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