2012
DOI: 10.18632/aging.100499
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Gene expression changes in response to aging, heat stress, hyperoxia, hydrogen peroxide, and ionizing radiation were compared using microarrays. A set of 18 genes were up-regulated across all conditions, indicating a general stress response shared with aging, including the heat shock protein (Hsp) genes Hsp70, Hsp83 and l(2)efl, the glutathione-S-transferase gene GstD2, and the mitochondrial unfolded protein response (mUPR) gene ref(2)P. Selected gene expression changes were confirmed using quantitative PCR, N… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

9
121
0

Year Published

2014
2014
2015
2015

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 105 publications
(130 citation statements)
references
References 65 publications
(130 reference statements)
9
121
0
Order By: Relevance
“…Its defensive role in multiple neurodegenerative disorders (15,16) can be explained by the multifaceted action of this protein. Indeed, the induction of Hsp70 has been shown to diminish oxidative stress damage (17,18), suppress apoptosis (19), support proteasomal and lysosomal functioning (20), suppress toxic protein aggregation such as Aβ (21), inhibit proinflammatory signaling (22), and increase survival of endogenous neural progenitor cells (21). Notwithstanding Hsp70's importance, its chaperone activity, as well as the rate of its synthesis and induction in response to stimuli, decreases in neurons with age (3,6,21,22), suggesting that a pharmacological approach aiming to recover this chaperone in the aging brain may counter neurodegeneration.…”
mentioning
confidence: 99%
“…HSPs can counteract proteo-toxicity and favor stress resistance to the organism which may be causally linked to an increase in life span vis-à-vis positive impact on the aging-related functional declines (Tower 2009(Tower , 2011. Genome-wide studies on age-associated gene expression changes in flies have shown the upregulation of heat shock genes (hsps) (Curtis et al 2007;Landis et al 2012). In addition, modulated expression of hsps (hsp70, hsp27, and hsp22) has been reported to alter life span in flies (Kim et al 2010;Liao et al 2008;Tatar et al 1997) and higher level of HSPs is reported in longerlived mammals and birds (Salway et al 2011).…”
mentioning
confidence: 99%
“…Among 449 genes with abnormally high transcripts in the head of flies exposed to hyperoxia, 68 are also upregulated in flies challenged by dietary administration of hydrogen peroxide or other protocols that cause oxidative stress [31]. Tens of genes are regulated by oxidative stress (regardless of whether this condition is caused by hyperoxia or hydrogen peroxide) and also by heat stress or ionizing radiation [44]. Some genes are regulated both by tunicamycin (which induces a form of ER stress) and by oxidative stress caused either by hydrogen peroxide or paraquat [33].…”
Section: Immune Response Genes Are Overrepresented During the Responsmentioning
confidence: 99%
“…Some genes are regulated both by tunicamycin (which induces a form of ER stress) and by oxidative stress caused either by hydrogen peroxide or paraquat [33]. At least for some of the genes regulated upon a variety of challenges it is reasonably well established that their regulation confers tolerance or protection against the experimental challenge [31,33,43,44]. …”
Section: Immune Response Genes Are Overrepresented During the Responsmentioning
confidence: 99%
“…The main pathological changes that drive AMD are inflammation and oxidative and endoplasmic reticulum (ER) stress. 1,2 There is evidence that the development of AMD is associated with changes in expression and in functional activity of a small heat shock protein, 3 a-crystallin, 4 originally known as one of the structural proteins of the lens. 5 a-Crystallin is a soluble cytosolic protein, but it is also localized within subcellular organelles including mitochondria and ER.…”
Section: Introductionmentioning
confidence: 99%