Gene expression and mental disease

Harrison, Paul J.; Pearson, R.C.A.

doi:10.1017/s0033291700005511

Cited by 9 publications

(1 citation statement)

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“…Gene expression encompasses those processes by which proteins are produced using the information provided by each encoding gene (Harrison & Pearson, 1989). It can be simplified into three stages.…”

Section: Introductionmentioning

confidence: 99%

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

et al. 1991

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SYNOPSISMessenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly less poly(A) + mRNA than controls in hippocampus (field CA3) and cerebellum (granule cell layer). Analysis of constituent pyramidal neurons showed mean reductions per cell within AD hippocampus (field CA3) and temporal cortex, but not in visual cortex. Similar changes were seen in a small group of non-AD dementias. The finding of reduced poly(A) + mRNA content is another indication of the altered brain gene expression occurring in AD. It is proposed that measurement of poly(A) + mRNA may be valuable in identifying functionally impaired neuronal populations. The methodology also provides a means by which changes in the quantitative distribution of individual mRNAs can be determined relative to that of poly(A) + mRNA as a whole.

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Section: Introductionmentioning

confidence: 99%

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

et al. 1991

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Molecular Genetics of Schizophrenia

McGuffin

Gill

1992

Genetic Research in Psychiatry

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isolation, but the colour of the main bag differs from the colour of the segments that remain sterile, presumably because of the tiny initial inoculum per unit volume.12 Whether this sign will turn out to be useful in screening blood remains to be seen. The Centers for Disease Control in Atlanta have suggested testing each unit over 25 days old for the presence ofbacteria before transfusion.7 This would entail breaching the closed system and conventional culture would result in unacceptable delays. The Food and Drug Administration has not found currently available rapid screening tests for bacteria such as Gram and acridine orange staining and endotoxin assays to be reliable in tests on "spiked" units.8 A rapid test based on the presence of bacterial 16S ribosomal RNA is currently undergoing trials with encouraging results (K Piper et al, 92nd general meeting of American Society for Microbiology, New Orleans, 26-30 May 1992). In the meantime, it should be emphasised that the reaction to contaminated blood may clinically resemble that to incompatible blood. Standard microbiological investigation with Gram staining and culture of donor blood (or platelets) at 20°C and 37°C is indicated after any severe transfusion reaction with no obvious serological cause. After transfusion has been stopped fever and hypotension should prompt antimicrobial treatment with drugs likely to act against most Gram negative contaminating organisms (for example, iprofloxacin or ceftazidime). Treatment with anti-endotoxin seems logical in cases of strongly suspected or confirmed bacterial contamination of blood or platelet transfusion, although there have been no reports of this application. To enable the delineation of the extent of the problem any suspected cases should be fully investigated and reported to the

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The molecular genetics of schizophrenia: An overview and forward view

McGuffin

1991

Eur Arch Psychiatry Clin Nuerosci

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Gene expression and mental disease

Cited by 9 publications

References 50 publications

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

Molecular Genetics of Schizophrenia

The molecular genetics of schizophrenia: An overview and forward view

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