Gene-53. Sex-Specific Gene and Pathway Modeling of Inherited Glioma Risk

Abstract

NEURO-ONCOLOGY • NOVEMBER 2017those tumors according to the glioma methylome-based signatures. RESULTS: The majority of cancer samples fell into the glioma IDH-wtlike group (98.5%). Within it, glioma-IDH-wt-K3-like subtype (n=3147) had a significant better overall survival (OS) than glioma-mesenchymallike (n=3670) and glioma-classic-like (n=658) subgroups (p=2e-16), resembling the behavior of the correspondent glioma subtypes. In contrast to gliomas, in which G-CIMP-low subtype had poorer OS than G-CIMP-high and codels, no significant differences in OS were found among the IDHmutant subtypes. In the IDH-mut-like pan-cancer group, G-CIMP-high/ low subtypes and glioma-codel-like presented none or only 3% IDH mutations, respectively. CONCLUSION: The pan-cancer glioma-methylome signatures revealed that most of human tumors fall into the glioma IDH-wt subtype with similar OS pattern as in gliomas. Among the IDH-mutantlike pan-cancer subtype, the OS were similar among subgroups. IDH was not mutated in the CIMP-like cancer group, suggesting that although these tumors resemble the G-CIMP molecular profile, the molecular mechanisms that may drive the epigenetic phenotype and OS in those tumors are yet to be determined.