Gender, Ethnicity, and Genes in Cardiovascular Disease.

Schaefer, Benjamin M.; Caracciolo, Vincent; Frishman, William H.; Charney, Pamela

doi:10.1097/01.hdx.0000074437.07268.00

Cited by 11 publications

(3 citation statements)

References 120 publications

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“…The high susceptibility of this Argentine and Uruguayan population to show MI at the evening points out to the relevance of variations in the spectrum of cardiovascular disease between different regions of the world and ethnic groups [ 21 - 25 ]. Indeed, it has been suggested that environmental-genetic background, socio-economic, and customs could underlie ethnic disparities in cardiovascular risk factor profiles [ 30 , 31 ]. A recent study confirms the existence of ethnic disparities in cardiovascular risk prevalence [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Circadian analysis of myocardial infarction incidence in an Argentine and Uruguayan population

D'Negri

Nicola-Siri

Vigo

et al. 2006

BMC Cardiovasc Disord

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BackgroundThe occurrence of variations in the spectrum of cardiovascular disease between different regions of the world and ethnic groups have been the subject of great interest. This study report the 24-h variation of myocardial infarction (MI) occurrence in patients recruited from CCU located in Argentina and Uruguay.MethodsA cohort of 1063 patients admitted to the CCU within 24 h of the onset of symptoms of an acute MI was examined. MI incidence along the day was computed in 1 h-intervals.ResultsA minimal MI incidence between 03:00 and 07:00 h and the occurrence of a first maximum between 08:00 and 12:00 h and a second maximum between 15:00 and 22:00 h were verified. The best fit curve was a 24 h cosinor (acrophase ~ 19:00 h, accounting for 63 % of variance) together with a symmetrical gaussian bell (maximum at ~ 10:00 h, accounting for 37 % of variance). A similar picture was observed for MI frequencies among different excluding subgroups (older or younger than 70 years; with or without previous symptoms; diabetics or non diabetics; Q wave- or non-Q wave-type MI; anterior or inferior MI location). Proportion between cosinor and gaussian probabilities was maintained among most subgroups except for older patients who had more MI at the afternoon and patients with previous symptoms who were equally distributed among the morning and afternoon maxima.ConclusionThe results support the existence of two maxima (at morning and afternoon hours) in MI incidence in the Argentine and Uruguayan population.

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Section: Discussionmentioning

confidence: 99%

Circadian analysis of myocardial infarction incidence in an Argentine and Uruguayan population

D'Negri

Nicola-Siri

Vigo

et al. 2006

BMC Cardiovasc Disord

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“…In addition, past trials for CAD management in women have included the use of hormone replacement therapy (HRT). This treatment strategy is no longer in practice owing to studies that demonstrated increased risk of adverse cardiac events in women on HRT [15].…”

Section: Noninvasive Management Of Coronary Artery Diseasementioning

confidence: 97%

Current trends in coronary artery disease in women

Chambers

Bagai

Ivascu

2007

Current Opinion in Anaesthesiology

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Despite significant advances in medical and surgical approaches to treat coronary artery disease, it remains and will continue to be the most important healthcare challenge of the 21st century. Whereas efforts are underway to encourage inclusion of more women in therapeutic trials, the educational process, particularly in medical school, needs to broadly address sex specific pathophysiology and treatment, rather than relying on sub-subspecialty training for optimizing healthcare delivery in women.

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“…Discordant results were reported so far on the role of such variants as risk factors for venous thrombosis, mainly because: i) heterogeneous criteria have been used so far to select the patients; ii) most studies pooled male and female patients and women are frequently underrepresented [10] thus obscuring eventual sex differences [7,11]; iii) some studies compared the frequency of prothrombotic gene variants in patients and controls of different geographical areas. Finally, as regards the clinical context, the ordering of tests for thrombophilia is strongly heterogeneous [12] and scarcerly respective of guidelines [13].…”

Section: Introductionmentioning

confidence: 99%

Molecular analysis of prothrombotic gene variants in venous thrombotic diseases. Different risk factors in different sex and clinical forms.

Cernera¹,

Amato²,

Elce³

et al. 2019

Preprint

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Background The role of prothrombotic gene variants as risk factors for venous thrombotic diseases is controversial and the ordering of tests for thrombophilia in the clinical context is scarcerly respective of evidence-based data. Methods We studied FVL, FVR2, FII G20210A, MTHFR C677T and A1298C, beta-fibrinogen -455 G>A, FXIII V34L, HPA-1 L33P variants and PAI-1 4G/5G alleles in: 343 patients with deep vein thrombosis (DVT), 164 with pulmonary embolism (PE), 126 with superficial vein thrombosis (SVT), 118 with portal vein thrombosis (PVT), 75 with cerebral vein thrombosis (CVT), 119 with retinal vein thrombosis (RVT) in comparison with 430 subjects from the general population (GP) of the same geographical area (Southern Italy). Results About 40% of patients with DVT, PE and SVT have a prothrombotic predisposition represented by FVL, FVR2 and FII G20210A variants (significantly more frequent than in the general population), significantly higher in PE males. While, in patients with PVT and CVT only FII G20210A variant is more frequent particularly in females. Finally, RVT is poorly related to prothrombotic risk factors, confirming that local vascular and other factors have a pivotal role in its pathogenesis. Conclusions Our data indicate that only FVL, FVR2 and FII G20210A are related to vein thrombotic diseases while all the other gene variants, frequently ordered in the clinical context, do not have a role as risk factors. Furthermore, the evidence of a sex difference for some variants, once confirmed in larger populations, may help to promote sex-specific prevention of such diseases.

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Gender, Ethnicity, and Genes in Cardiovascular Disease.

Cited by 11 publications

References 120 publications

Circadian analysis of myocardial infarction incidence in an Argentine and Uruguayan population

Circadian analysis of myocardial infarction incidence in an Argentine and Uruguayan population

Current trends in coronary artery disease in women

Molecular analysis of prothrombotic gene variants in venous thrombotic diseases. Different risk factors in different sex and clinical forms.

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