Gender Differences in Mouse Skin Morphology and Specific Effects of Sex Steroids and Dehydroepiandrosterone

Azzi, Lamia; El‐Alfy, Mohamed; Martel, Céline; Labrie, Fernand

doi:10.1111/j.0022-202x.2004.23545.x

Cited by 145 publications

(129 citation statements)

References 21 publications

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“…Skin is not traditionally considered a sex hormone-responsive tissue; however, studies have shown that such hormones can have a significant influence on the skin. Studies by Azzi et al (39) showed gender differences in mouse skin morphology, an effect of gonadectomy on skin structure, and an influence of exogenous estrogen and estrogen precursors on skin histology. Postmenopausal women with diminished systemic estrogen production show significant changes in the skin, including delayed wound healing, skin thinning, and increased wrinkling, all of which can be reversed with hormone replacement therapy (40).…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in UVB-Induced Skin Carcinogenesis, Inflammation, and DNA Damage

Thomas‐Ahner¹,

Wulff²,

Tober³

et al. 2007

Cancer Research

133

136

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The American Cancer Society reports the incidence of squamous cell carcinoma in males to be thrice the incidence in females. This increased squamous cell carcinoma incidence has been attributed to men accumulating more sun exposure and using less sun protection than women. To date, there have been no controlled studies examining the effect of gender on skin tumor development following equal doses of UVB. Gender differences in UVB-induced skin carcinogenesis were examined using the Skh-1 mouse model. After chronic exposure to equal doses of UVB, male mice developed tumors earlier and had more tumors than female mice; tumors in male mice tended to be larger, and the total tumor burden was greater than in females. In addition, tumors in males were of more advanced histologic grade compared with those of female mice. To evaluate the contribution of differences in inflammation and DNA damage to differences in skin carcinogenesis, male and female Skh-1 mice were exposed once to 2,240 J/m 2 UVB and examined 48 h after exposure. Surprisingly, male mice developed less of an inflammatory response, as determined by skin fold thickness and myeloperoxidase activity, compared with females. Interestingly, male mice showed more cutaneous oxidative DNA damage than the females and lower antioxidant levels. These results show a gender bias in skin carcinogenesis and suggest that the gender difference in tumor development is more influenced by the extent of oxidative DNA damage and antioxidant capacities than by inflammatory response. [Cancer Res 2007;67(7):3468-74]

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Section: Discussionmentioning

confidence: 99%

Gender Differences in UVB-Induced Skin Carcinogenesis, Inflammation, and DNA Damage

Thomas‐Ahner¹,

Wulff²,

Tober³

et al. 2007

Cancer Research

133

136

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“…5 mm) (Sensyu Kagaku, Tokyo) were used. The column oven was set to 30 C. The elution program was a linear gradient with 87.5:12:0.5 (vol/vol/vol) chloroform:methanol:triethylamine buffer (pH 3, 1 M formic acid) at t ¼ 0 min to 28:60:12 (vol/vol/vol) at t ¼ 26 min. The mobile phase was kept at 28:60:12 (vol/vol/vol) chloroform:methanol:triethylamine for a further 4 min.…”

Section: Methodsmentioning

confidence: 99%

“…It has been reported that gender differences affect skin morphology due to sex hormones. 30) Estrogen, a famous female Cer, ceramides; Ch, cholesterol hormone, increases the skin collagen content and thus maintains skin thickness and elasticity, and that maintains the skin water content.…”

Section: Content Of Ceramides In Stratum Corneummentioning

confidence: 99%

Dietary Phospholipid Concentrate from Bovine Milk Improves Epidermal Function in Hairless Mice

Haruta¹,

Kato²,

Yoshioka³

2008

Bioscience, Biotechnology, and Biochemistry

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We investigated the effect of dietary phospholipid (PL) concentrate from bovine milk on the epidermis. Thirteen-week-old hairless male and female mice (Hos:HR-1) were separated into two experimental groups, each fed two experimental diets: the control group and the PL group. The mice were given the experimental diets for 6 weeks. Stratum corneum hydration and transepidermal water loss (TEWL) were measured using Corneometer CM825 and Tewameter TM300 (Courage and Khazaka Electronics, Cologne, Germany) at 3 weeks and 6 weeks. After the feeding period, ceramides in stratum corneum were analyzed. We found that stratum corneum hydration and ceramides in the PL group were significantly higher than those in the control group and that TEWL in the PL group tended to decrease.These results indicate that dietary PL concentrate improves epidermal function by increasing the amount of ceramides, resulting in higher hydration.

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“…A recent study has demonstrated that in response to Staphylococcus aureus skin infections in C57BL/6J mice, dermal preadipocytes proliferate and protect against the infection (31). In addition, a previous study has shown that sex plays an important role in skin morphology and physiology (32). Based on these studies, we hypothesized a similar proliferation against GAS skin infections; also, we wanted to determine whether there are any marked sex-based differences in this proliferation.…”

Section: Resultsmentioning

confidence: 96%

Host Genetic Variations and Sex Differences Potentiate Predisposition, Severity, and Outcomes of Group A Streptococcus-Mediated Necrotizing Soft Tissue Infections

et al. 2016

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bHost genetic variations play an important role in several pathogenic diseases, and we previously provided strong evidence that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive group A Streptococcus (GAS) patients, including sepsis and necrotizing soft tissue infections (NSTIs). The goal of the present study was to investigate how genetic variations and sex differences among four commonly used mouse strains contribute to variation in severity, manifestations, and outcomes of NSTIs. DBA/2J mice were more susceptible to NSTIs than C57BL/6J, BALB/c, and CD-1 mice, as exhibited by significantly greater bacteremia, excessive dissemination to the spleen, and significantly higher mortality. Differences in the sex of the mice also contributed to differences in disease severity and outcomes: DBA/2J female mice were relatively resistant compared to their male counterparts. However, DBA/2J mice exhibited minimal weight loss and developed smaller lesions than did the aforementioned strains. Moreover, at 48 h after infection, compared with C57BL/6J mice, DBA/2J mice had increased bacteremia, excessive dissemination to the spleen, and excessive concentrations of inflammatory cytokines and chemokines. These results indicate that variations in the host genetic context as well as sex play a dominant role in determining the severity of and susceptibility to GAS NSTIs. Streptococcus pyogenes or group A streptococci (GAS) are the causative agents of a multitude of human diseases ranging from nonsevere strep throat, pharyngitis, and impetigo to lifethreatening necrotizing soft tissue infections (NSTIs) and streptococcal toxic shock syndrome (STSS) (1-12). The multifaceted nature of invasive GAS infections requires several modes of pathogenic adaptation to evade host immune defenses to successfully colonize and survive in host niches. In addition to the plethora of pathogenic factors contributing to disease severity, variations in the host genetic context play an equally important role in manipulating disease severity, manifestations, and outcomes.The emergence of virulent strains of GAS bacteria in the early 1980s coincided with a remarkable resurgence of severe and often deadly forms of invasive infections associated with STSS and NSTIs (5,6,12,13). One particular strain that emerged during that time is the clonal M1T1 strain that disseminated globally and continues to be one of the most prevalently isolated strains from patients with invasive and/or noninvasive GAS infections (12,(14)(15)(16)(17). This strain produces many secreted and surface-bound virulence factors; most of them are adapted to evade human host defense mechanisms (12, 18). However, previous studies from our laboratory characterized indistinguishable, invasive M1T1 isolates from patients with starkly different disease severity and outcomes (19). These findings underscored the contribution of host factors to the stark differences in severity and outcomes of invasive GAS infections.Indeed, ensuing ...

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Gender Differences in Mouse Skin Morphology and Specific Effects of Sex Steroids and Dehydroepiandrosterone

Cited by 145 publications

References 21 publications

Gender Differences in UVB-Induced Skin Carcinogenesis, Inflammation, and DNA Damage

Gender Differences in UVB-Induced Skin Carcinogenesis, Inflammation, and DNA Damage

Dietary Phospholipid Concentrate from Bovine Milk Improves Epidermal Function in Hairless Mice

Host Genetic Variations and Sex Differences Potentiate Predisposition, Severity, and Outcomes of Group A Streptococcus-Mediated Necrotizing Soft Tissue Infections

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