Gender differences in colorectal cancer survival: A meta‐analysis

Yang, Yanming; Wang, Guiying; He, Jun; Ren, Shengxiang; Wu, Fengpeng; Zhang, Jianfeng; Wang, Feifei

doi:10.1002/ijc.30827

Cited by 132 publications

(112 citation statements)

References 53 publications

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“…The assayed merged subgroups showed a trend for saturation for more than 10 samples for CRC and about 20 samples for the control group, whereupon the number of proteins in the summarized proteomes was increased insignificantly. Although there are data regarding the gender-specific difference in overall survival and cancer-specific survival for CRC patients [19], unfortunately, this kind of anthropometric stratification would have been almost impossible within the frame of this study because it would have given even smaller sizes of subgroups with no possibility to review and apply any statistical significance. The common part of the proteome shared between all the groups was determined by comparative analysis.…”

Section: Resultsmentioning

confidence: 99%

Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development

et al. 2020

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Background: Colorectal cancer (CRC) at a current clinical level is still hardly diagnosed, especially with regard to nascent tumors, which are typically asymptotic. Searching for reliable biomarkers of early diagnosis is an extremely essential task. Identification of specific post-translational modifications (PTM) may also significantly improve net benefits and tailor the process of CRC recognition. We examined depleted plasma samples obtained from 41 healthy volunteers and 28 patients with CRC at different stages to conduct comparative proteome-scaled analysis. The main goal of the study was to establish a constellation of protein markers in combination with their PTMs and semi-quantitative ratios that may support and realize the distinction of CRC until the disease has a poor clinical manifestation. Results: Proteomic analysis revealed 119 and 166 proteins for patients in stages I–II and III–IV, correspondingly. Plenty of proteins (44 proteins) reflected conditions of the immune response, lipid metabolism, and response to stress, but only a small portion of them were significant (p < 0.01) for distinguishing stages I–II of CRC. Among them, some cytokines (Clusterin (CLU), C4b-binding protein (C4BP), and CD59 glycoprotein (CD59), etc.) were the most prominent and the lectin pathway was specifically enhanced in patients with CRC. Significant alterations in Inter-alpha-trypsin inhibitor heavy chains (ITIH1, ITIH2, ITIH3, and ITIH4) levels were also observed due to their implication in tumor growth and the malignancy process. Other markers (Alpha-1-acid glycoprotein 2 (ORM2), Alpha-1B-glycoprotein (A1BG), Haptoglobin (HP), and Leucine-rich alpha-2-glycoprotein (LRG1), etc.) were found to create an ambiguous core involved in cancer development but also to exactly promote tumor progression in the early stages. Additionally, we identified post-translational modifications, which according to the literature are associated with the development of colorectal cancer, including kininogen 1 protein (T327-p), alpha-2-HS-glycoprotein (S138-p) and newly identified PTMs, i.e., vitamin D-binding protein (K75-ac and K370-ac) and plasma protease C1 inhibitor (Y294-p), which may also contribute and negatively impact on CRC progression. Conclusions: The contribution of cytokines and proteins of the extracellular matrix is the most significant factor in CRC development in the early stages. This can be concluded since tumor growth is tightly associated with chronic aseptic inflammation and concatenated malignancy related to loss of extracellular matrix stability. Due attention should be paid to Apolipoprotein E (APOE), Apolipoprotein C1 (APOC1), and Apolipoprotein B-100 (APOB) because of their impact on the malfunction of DNA repair and their capability to regulate mTOR and PI3K pathways. The contribution of the observed PTMs is still equivocal, but a significant decrease in the likelihood between modified and native proteins was not detected confidently.

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Section: Resultsmentioning

confidence: 99%

Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development

et al. 2020

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“…A sex-related immunogenic variability after surgical stress has been observed in experimental models, and this might influence outcomes after colon surgery. In the long term this can be associated with higher rates of survival, as suggested by a recent meta-analysis which found that women had better cancer-related survival than men (HR = 0.92, 95% CI = 0.89-0.95) [16]. Visceral obesity makes surgery more difficult, but the increased incidence of AL in this group may also be related to the metabolic effect of obesity.…”

Section: Patient-related Factorsmentioning

confidence: 99%

“…Perforation was not significantly higher after stent placement (3.1% vs 4.8%, no stent vs stent, P = 0.48). The median number of nodes isolated from the specimen was 14 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Pathology and Perioperative Outcomementioning

confidence: 99%

Predictors of complications and mortality following left colectomy with primary stapled anastomosis for cancer: results of a multicentric study with 1111 patients

et al. 2018

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“…Regardless of T2D, CRC incidence, prevalence, and mortality are higher among men than women [5, 6]. However, women aged ≥ 55 years are more often diagnosed with proximal (right-sided) CRC [7], which is associated with more aggressive form of neoplasia than distal (left-sided) CRC [8].…”

Section: Introductionmentioning

confidence: 99%

Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes

Overbeek

Kuiper

Heijden³

et al. 2018

Int J Colorectal Dis

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PurposeThe prevalence of colorectal cancer is higher among patients with type 2 diabetes mellitus (T2D) than among patients without diabetes. Furthermore, men are at higher risk for developing colorectal cancer than women in the general population and also subsite-specific risks differ per sex. The aim was to evaluate the impact of T2D on these associations.MethodsA population-based matched cohort study was performed using data from the PHARMO Database Network. Patients with T2D were selected and matched (1:4) to diabetes free controls. Cox proportional hazards models were used to estimate hazard ratios (HRs) for CRC and its subsites. HRs were determined per sex and adjusted for age and socioeconomic status. The ratio of distal versus proximal colon cancer was calculated for people with T2D and controls per sex and stratified by age.ResultsOver 55,000 people with T2D were matched to > 215,000 diabetes free controls. Men and women with T2D were 1.3 times more likely to develop colorectal cancer compared to controls. Men with T2D were at higher risk to develop distal colon cancer (hazard ratio (95% confidence interval), 1.42 (1.08–1.88)), and women with T2D were at higher risk for developing proximal colon cancer (hazard ratio (95% confidence interval), 1.58 (1.13–2.19)). For rectal cancer, no statistically significant risk was observed for both men and women.ConclusionsSex-specific screening strategies and prevention protocols should be considered for people with T2D. More tailored screening strategies may optimize the effectiveness of colorectal cancer screening in terms of reducing incidence and mortality.Electronic supplementary materialThe online version of this article (10.1007/s00384-018-3191-7) contains supplementary material, which is available to authorized users.

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Gender differences in colorectal cancer survival: A meta‐analysis

Cited by 132 publications

References 53 publications

Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development

Revelation of Proteomic Indicators for Colorectal Cancer in Initial Stages of Development

Predictors of complications and mortality following left colectomy with primary stapled anastomosis for cancer: results of a multicentric study with 1111 patients

Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes

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