Gender and the placebo analgesic effect in acute pain

Averbuch, Mordechai; Katzper, Meyer

doi:10.1067/mcp.2001.118366

Cited by 56 publications

(33 citation statements)

References 23 publications

(34 reference statements)

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“…Increasing evidence indicates that women may be more responsive than men to sensory smoking cues, which suggests that they might show greater placebo effects of smoking (e.g., Perkins, Donny & Caggiula, 1999;Perkins et al, 2001) and perhaps NRT. By contrast, clinical research has shown no sex differences in analgesic placebo effects (Averbuch & Katzper, 2001), and greater effects in men than women have been seen in placebo effects of antidepressant medications (Wilcox et al, 1992). Regarding personality factors, the common notion that certain individuals have personalities that make them generally more susceptible to placebo responding has not been supported in the placebo literature (e.g., Bootzin & Caspi, 2002).…”

Section: Individual Differences In Placebo Nicotine Responsesmentioning

confidence: 92%

Placebo effects of tobacco smoking and other nicotine intake

Perkins

Sayette

Conklin

et al. 2003

Nicotine & Tobacco Research

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Nicotine intake is a necessary but insufficient factor in maintaining tobacco smoking behavior, and nonpharmacological factors associated with smoking play a key role. Some of these factors may influence smoking behavior by eliciting placebo effects, or responses related specifically to the belief that one is consuming a drug. Greater knowledge of placebo effects of smoking would improve our understanding of factors that maintain smoking behavior, thereby aiding efforts to develop treatments to counter the influence of these factors. In addition, better understanding of placebo effects from other means of nicotine intake could help determine mechanisms of the therapeutic actions of nicotine replacement therapy, perhaps enhancing its efficacy in smoking cessation. Placebo effects of smoking or other nicotine intake have received little research attention. In this review, we first discuss common terms and methods of placebo research, especially the balanced-placebo design. We then examine the limited research directly assessing placebo effects of smoking and other nicotine intake, namely studies that manipulated instructions to subjects about the drug content of an ingested substance. Finally, we examine other studies relevant to gauging the likely magnitude of placebo smoking effects. In an effort to encourage more research on these placebo effects, we pay substantial attention to future directions. Among recommendations are testing the utility of the balanced-placebo design and other rigorously controlled designs, and including multiple measures of placebo effects in addition to self-report. Future research also should explore the moderating influences of the environmental context and of individual difference factors on placebo effects of smoking and other nicotine intake.

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Section: Individual Differences In Placebo Nicotine Responsesmentioning

confidence: 92%

Placebo effects of tobacco smoking and other nicotine intake

Perkins

Sayette

Conklin

et al. 2003

Nicotine & Tobacco Research

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“…There are, however, a few findings of stronger placebo analgesic responses in males (Berkley et al 2006;Fillingim et al 2009). Others failed to find SGD in placebo response in the post-third molar extraction (Averbuch and Katzper 2001), in transcutaneous electrical stimulation setting (Robinson et al 1998), and pressure algometer test (Olofsen et al 2005). A systemic review of literature shows that placebo response is not sex related in fibromyalgia and painful peripheral diabetic neuropathy (Hauser et al 2011).…”

Section: Sgd In Placebo Analgesiamentioning

confidence: 96%

Sex and Gender in Adverse Drug Events, Addiction, and Placebo

Franconi

Campesi

Occhioni

et al. 2012

Handbook of Experimental Pharmacology

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Sex-gender-based differences in response to pharmaceutical treatments are still under evaluation but evidence already exists regarding the impact of sex-gender-related differences on drug safety profile, drug abuse/addiction, and placebo effects. For a number of drugs it is well recognized that a sex-gender dimorphic profile in terms of drug adverse effects exists and appears to be more frequent and severe in women than in men. However, it is not well known whether this is due to pharmacodynamic or pharmacokinetic differences. Indeed the optimization of therapy requires that attention is paid to single sex-gender. Numerous pharmacokinetic, pharmacodynamic, and sociocultural differences between women and men in drug abuse have been described. Here we focus on sex-gender differences in alcoholism and nicotine addiction. The relevance of sex and gender differences in addiction appear to be relevant. Specific programs aimed to address addicted women's specific needs (child care, pregnancy, housing, and violence and others) are recommended. Finally, this article discusses the possible effect of sex-gender on placebo response in the light of the more significant recent literature evidencing that studies are urgently required in order to better understand the role of sex-gender on placebo mechanism and its impact on randomized clinical trials outcomes.

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“…Requiring a 50% symptom improvement to qualify as a treatment responder resulted in 26% placebo responders in diabetic neuropathic pain (Arakawa et al, 2015) but this was lower in other pain conditions (e.g., dental pain: 16%; Averbuch and Katzper, 2001). Similar response rates were reported in migraine (29%; Macedo et al, 2006), fibromyalgia (45%; Hauser et al, 2011), and pancreatic pain (20%; Capurso et al, 2012) investigations.…”

Section: A Effect Sizes Of Symptom Improvement Across Different Medimentioning

confidence: 99%