2015
DOI: 10.1038/ncomms10033
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Abstract: Reptiles are the most morphologically and physiologically diverse tetrapods, and have undergone 300 million years of adaptive evolution. Within the reptilian tetrapods, geckos possess several interesting features, including the ability to regenerate autotomized tails and to climb on smooth surfaces. Here we sequence the genome of Gekko japonicus (Schlegel's Japanese Gecko) and investigate genetic elements related to its physiology. We obtain a draft G. japonicus genome sequence of 2.55 Gb and annotated 22,487 … Show more

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Cited by 142 publications
(142 citation statements)
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“…It is syntenic with the CBP locus of the green anole lizard and with the main CBP loci of birds and turtles3033. Within the CBP gene cluster, 35 and 36 CBP genes, here termed Beta1 through Beta36 in order of the arrangement of the genes, were identified in the python and cobra, respectively, which is comparable to the 40 CBP genes present in the green anole lizard26, but lower than the 71 CBP genes reported for the Japanese gecko39.…”
Section: Resultsmentioning
confidence: 70%
See 1 more Smart Citation
“…It is syntenic with the CBP locus of the green anole lizard and with the main CBP loci of birds and turtles3033. Within the CBP gene cluster, 35 and 36 CBP genes, here termed Beta1 through Beta36 in order of the arrangement of the genes, were identified in the python and cobra, respectively, which is comparable to the 40 CBP genes present in the green anole lizard26, but lower than the 71 CBP genes reported for the Japanese gecko39.…”
Section: Resultsmentioning
confidence: 70%
“…1) suggest that gene innovations or gene losses have occurred in either one of the evolutionary lineages leading to snakes and iguanians (represented here by A. carolinensis ). To determine the ancestral condition for each of the clade-specific genes, we searched for orthologous genes in the Japanese gecko ( G. japonicus ), representing Gekkota, a basal clade of squamates and the closest outgroup to Toxicofera444546 with a sequenced genome39. These comparisons suggested that some EDC genes have been lost in snakes whereas others have originated in the snake lineage.…”
Section: Resultsmentioning
confidence: 99%
“…An additional local assembly for reads with one end of a read pair uniquely aligned to a contig and the other end located within the gap was performed using GapCloser [2]. The end result was a leopard gecko genome assembly with a total length of 2.0 Gb and scaffold and contig N50s of 664 and 20 kb, respectively, which is comparable to the previously reported Gekko japonicus genome assembly (Table 3) [4]. Comparison of assembly N50s for the leopard gecko genome with eleven previously published reptile genomes ( Anolis carolinensis [5], Python molurus bivittatus [6], Ophiophagus hannah [7], Alligator sinensis [8, 9], Alligator mississippiensis , Gavialis gangeticus , Crocodylus porosus [10], Chelonia mydas , Pelodiscus sinensis [11], Pogona vitticeps [12], and Chrysemys picta bellii [13]) further confirmed that our results were of comparable or better quality (Table 4).…”
Section: Data Descriptionmentioning
confidence: 56%
“…However, this appears to have been facilitated by the reconfiguration of the cone photoreceptors to dim light-adapted cells, rendering rods superfluous. As such, rod-specific genes are expected to be inactivated, with evidence for a rod opsin ( RH1 ) pseudogene coming from a gecko genome 72. These species may be excellent models for congenital night blindness in humans…”
Section: Amelogenesis Imperfectamentioning
confidence: 99%