Gefitinib: A Cause of Pyogenic Granulomalike Lesions of the Nail

High, Whitney A.

doi:10.1001/archderm.142.7.939-a

Cited by 17 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PG arises from various stimuli, including chronic low-grade irritation, traumatic injury, hormones and drugs. There are several reports of pharmaceutical PG associated with gefitinib or paclitaxel 5 6. Lim et al reported the development of PG under the administration of ramucirumab in 2015 1.…”

Section: Discussionmentioning

confidence: 99%

Development of pyogenic granuloma with strong vascular endothelial growth factor receptor-2 expression during ramucirumab treatment

et al. 2019

View full text Add to dashboard Cite

The angiogenesis inhibitor ramucirumab (IMC-1121B) is a fully humanised IgG1 monoclonal antibody targeting the extracellular domain of vascular endothelial growth factor receptor 2. Ramucirumab has been approved as a second-line treatment for lung cancer. Pyogenic granuloma is an acquired, benign vascular tumour of the skin or mucous membrane. We encountered a patient with pyogenic granuloma who was treated with ramucirumab. The patient was a 48-year-old Japanese woman with advanced lung cancer who had been heavily pretreated using several lines of chemotherapy. Ramucirumab was administered as the fifth-line treatment with docetaxel. After 10 days, a painless rice-coloured or pink papule appeared on her finger. One month later, it increased in size to 20 mm. We examined the pathological condition by immunostaining using the resected specimen diagnosed as pyogenic granuloma. Paradoxically, this vascular tumour arose during the administration of an angiogenesis inhibitor.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of pyogenic granuloma with strong vascular endothelial growth factor receptor-2 expression during ramucirumab treatment

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Development of EGFR inhibitors‐induced nail PGs is dose dependent, the growth increasing as dose is increased and waning usually after 1–2 months after stopping the drug. Topical steroids and antiseptics, together with local hygiene and avoiding friction and pressure by shoes, can be effective 21,22 . Lateral matricectomy with phenolization of affected toenails has been reported effective with no recurrence, indicating the predisposing role of trauma and nail morphology 23 …”

Section: Discussionmentioning

confidence: 99%

“…Topical steroids and anti- Ó 2010 The Authors septics, together with local hygiene and avoiding friction and pressure by shoes, can be effective. 21,22 Lateral matricectomy with phenolization of affected toenails has been reported effective with no recurrence, indicating the predisposing role of trauma and nail morphology. 23 Capecitabine is an oral chemotherapeutic agent of the fluoropyrimidine family that is converted to 5-fluorouracil by the enzyme thymidine phosphorylase, which is found in its highest concentration in tumour tissue.…”

Section: Discussionmentioning

confidence: 99%

Periungual and subungual pyogenic granuloma

Piraccini

Bellavista

Misciali

et al. 2010

British Journal of Dermatology

115

View full text Add to dashboard Cite

show abstract

“…Pyogenic granuloma is a common vascular lesion, but multiple periungueal pyogenic granulomas are rarely reported in the literature, usually related to drugs and other conditions. Different drugs have been reported as causative agents of multiple periungueal pyogenic granulomas, such as oral retinoids (both etretinate and isotretinoin), 5‐fluoruracil and its derivate capecitabine, the epidermal growth factor receptor inhibitor gefitinib, and antiretroviral therapies such as indinavir and lamivudine (1). Tosti et al (2) reported nine patients with periungueal pyogenic granulomas and onychomadesis following cast immobilization because of phalanx, metacarpal, and wrist fractures.…”

Section: Discussionmentioning

confidence: 99%