GDF15 and its association with cognitive performance over time in a longitudinal study of middle-aged urban adults

Beydoun, May A.; Hooten, Nicole Noren; Weiss, Jordan; Beydoun, Hind A.; Georgescu, Michael F.; Freeman, D.W.; Evans, Michele K.; Zonderman, Alan B.

doi:10.1016/j.bbi.2022.12.015

Cited by 10 publications

(2 citation statements)

References 43 publications

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“…These ndings resonate with and extend prior research, which traditionally focused on the association between neuropsychological performance and metrics like ICVF, Fractional Anisotropy, and Mean Diffusivity. Our study adds a new dimension by emphasizing the importance of the ISOVF index in understanding cognitive decline in AD, offering a fresh perspective on neuroimaging biomarkers' role in the disease 37 .…”

Section: Discussionmentioning

confidence: 99%

Cortical microstructural alterations along the Alzheimer’s disease continuum and association with amyloid and tau pathology

Zhang,

Hu,

et al. 2024

Preprint

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Multi-shell diffusion MRI offers considerable potential for the noninvasive mapping of Alzheimer’s disease (AD) pathology. Longitudinal studies examining the ability of Neurite Orientation Dispersion and Density Imaging (NODDI) technology to detect early neurodegenerative changes during AD’s preclinical stage are limited. Moreover, the correlation between cortical microstructural alterations and in vivo AD pathology, specifically amyloid and tau protein accumulation, requires further investigation. In this research, we assessed cortical microstructural changes across the AD spectrum, including 61 APOE-ɛ4 negative cognitively normal subjects, 28 APOE-ɛ4 positive cognitively normal subjects, 58 individuals with mild cognitive impairment, and 24 with AD dementia, as part of the Alzheimer’s Disease Neuroimaging Initiative. Assessments were made both cross-sectionally and longitudinally. We also examined the regional relationships between amyloid deposits, tau protein accumulation, and changes in cortical NODDI microstructure associated with AD. Our findings identified reductions in the Intracellular Volume Fraction, an increased isotropic volume fraction (ISOVF), and modifications to the Orientation Dispersion Index in AD-impacted regions. Notably, these modifications were observable across the AD continuum, including during preclinical stages. ISOVF, in particular, showed a positive correlation with the presence of tau and Aβ pathology in critical brain regions, potentially indicative of underlying neuroinflammation. Changes in NODDI metrics correlated with cognitive performance, especially in memory, and were found to partially mediate the link between tau pathology and cognitive function. These comprehensive results suggest NODDI’s potential as an early biomarker for AD detection, disease progression tracking, and therapeutic intervention, contributing fresh perspectives on the disease’s pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Cortical microstructural alterations along the Alzheimer’s disease continuum and association with amyloid and tau pathology

Zhang,

Hu,

et al. 2024

Preprint

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“…The secretion of mitokines, which are induced by MSR and UPR mt activation, also plays a critical role in regulating systemic metabolism and influencing the development of metabolic and aging-related diseases [ 62 ]. Dysregulation of mitokine signaling has been linked to the development of a wide range of diseases, including obesity, insulin resistance, and neurodegenerative disorders [ 63 , 64 ].…”

Section: Inter-tissue and Multi-organ Orchestration In Response To Mi...mentioning

confidence: 99%

Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases

Zhang,

Chang,

Lee

et al. 2024

Diabetes Metab J

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Mitochondrial stress and the dysregulated mitochondrial unfolded protein response (UPR<sup>mt</sup>) are linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Mitokines, signaling molecules released by mitochondrial stress response and UPR<sup>mt</sup>, are crucial mediators of inter-organ communication and influence systemic metabolic and physiological processes. In this review, we provide a comprehensive overview of mitokines, including their regulation by exercise and lifestyle interventions and their implications for various diseases. The endocrine actions of mitokines related to mitochondrial stress and adaptations are highlighted, specifically the broad functions of fibroblast growth factor 21 and growth differentiation factor 15, as well as their specific actions in regulating inter-tissue communication and metabolic homeostasis. Finally, we discuss the potential of physiological and genetic interventions to reduce the hazards associated with dysregulated mitokine signaling and preserve an equilibrium in mitochondrial stress-induced responses. This review provides valuable insights into the mechanisms underlying mitochondrial regulation of health and disease by exploring mitokine interactions and their regulation, which will facilitate the development of targeted therapies and personalized interventions to improve health outcomes and quality of life.

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Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and incident dementia: The UK Biobank study

Beydoun,

Noren Hooten

et al. 2024

GeroScience

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GDF15 and its association with cognitive performance over time in a longitudinal study of middle-aged urban adults

Cited by 10 publications

References 43 publications

Cortical microstructural alterations along the Alzheimer’s disease continuum and association with amyloid and tau pathology

Cortical microstructural alterations along the Alzheimer’s disease continuum and association with amyloid and tau pathology

Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases

Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and incident dementia: The UK Biobank study

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