Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2016
2016
2016
2016

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 9 publications
(8 reference statements)
0
1
0
Order By: Relevance
“…In C. elegans , amino acids and proteins are influencing its lifespan through DR. In this scope, it has been shown in a recent study that GCN2, the evolutionarily conserved kinase that directly responds to amino acid deficiency, plays a central role in mediating lifespan extension under DR conditions by converging with TOR/S6K signalling on the PHA-4/FoxA transcription factors and its downstream target genes under stressful conditions [ 75 , 76 ]. Reducing the uptake of peptides, by Pep-2 deletion, also increases lifespan by reducing insulin signalling [ 77 ] and, additionally, mutations in Metr-1/methionine synthase or the use of the common antidiabetic drug metformin, which alters methionine metabolism, is also known to extend lifespan in C. elegans [ 78 ].…”
Section: Nitrogen Sources As Key Effectors On Dietary Regimensmentioning
confidence: 99%
“…In C. elegans , amino acids and proteins are influencing its lifespan through DR. In this scope, it has been shown in a recent study that GCN2, the evolutionarily conserved kinase that directly responds to amino acid deficiency, plays a central role in mediating lifespan extension under DR conditions by converging with TOR/S6K signalling on the PHA-4/FoxA transcription factors and its downstream target genes under stressful conditions [ 75 , 76 ]. Reducing the uptake of peptides, by Pep-2 deletion, also increases lifespan by reducing insulin signalling [ 77 ] and, additionally, mutations in Metr-1/methionine synthase or the use of the common antidiabetic drug metformin, which alters methionine metabolism, is also known to extend lifespan in C. elegans [ 78 ].…”
Section: Nitrogen Sources As Key Effectors On Dietary Regimensmentioning
confidence: 99%