GC-MS combined with multivariate analysis for the determination of the geographical origin of <i>Elsholtzia rugulosa</i> Hemsl. in Yunnan province

Zheng, Chao-Pei; Yang, Shangbin; Huang, Dequan; Mao, Deshou; Chen, Jianhua; Zhang, Chengming; Kong, Wei-Song; Liu, Xin; Xu, Yong; Wu, Yiqin; Li, Zhengfeng; Wang, Jin; Ye, Yanqing

doi:10.1039/d2ra02876j

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…This study determined the percent composition of the main chemical metabolites of botanical drugs in DTX (see Supplementary Table S1 ). The main active metabolites of E. rugulosa were monoterpenes, sesquiterpenes, and flavonoids, which exert antipyretic, detoxifying, antioxidant, and UA-lowering effects ( Zheng et al, 2022 ). Moreover, the main active metabolites of P. tabuliformis were sesquiterpenes, terpene alcohol fractions, and flavonoids, such as α-pinene, which exert anti-inflammatory, UA-lowering, and renal protective effects ( Zheng et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Daitongxiao (DTX) has been used by the Dai people in Yunnan Province, China, for the treatment of “Longmengshahou” (HUA in modern medicine) for more than 2,500 years ( Zheng et al, 2022 ). The use of DTX to alleviate diseases caused due to elevated UA levels has been documented in the 21st century Dai medical undergraduate education book Clinical Science of Dai Medicine ( Wu et al, 2022 ; Zheng et al, 2022 ). Clinical studies have shown that out of 29 HUA patients treated with DTX (20 g/day/person, with a duration of 14 days), 25 patients had improved serum urate (SU) levels with an overall efficacy rate of 86.22%.…”

Section: Introductionmentioning

confidence: 99%

“…Experimental studies have reported that DTX can significantly downregulate serum UA, blood urea nitrogen (BUN), and creatinine (Cre) levels in the yeast powder-induced HUA mouse model ( Zheng et al, 2022 ), exerting renal protective effects. Previous studies have demonstrated that in the adenine + ethambutol hydrochloride-induced HUA rat model, DTX significantly increased urinary excretion of UA and decreased SU levels ( Liu F et al, 2024 ).…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative action of “daitongxiao” against hyperuricemia includes the “uric acid transporter group”

Zheng,

Bai,

Wan

et al. 2024

Front. Pharmacol.

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This study aimed to investigate the potential mechanisms involved in the therapeutic effects of daitongxiao (DTX) on hyperuricemia (HUA). DTX was administered to two animal models of HUA via gavage feeding: HUA quail model (a uricotelic animal with urate oxidase deficiency), treated continuously for 35 days post-HUA induction, and HUA rats (an animal with active urate oxidase), treated continuously for 28 days post-HUA induction. HUA was induced in quail by administering a solution of sterile dry yeast powder via gavage feeding, while in rats, it was induced by intragastric gavage feeding of a solution of adenine and ethambutol hydrochloride. DTX improved overall health; increased bodyweight; reduced renal index, serum urate levels, serum xanthine oxidase activity, blood urea nitrogen, and creatinine; and enhanced urinary and fecal uric acid (UA) excretion in these two animal models. The results of hematoxylin and eosin and hexamine silver staining of kidney sections revealed that DTX significantly mitigated HUA-induced renal structural damage and inflammatory response. The results of quantitative real-time polymerase chain reaction, Western blotting, and immunofluorescence analyses revealed that DTX downregulated the renal expression levels of glucose transporter 9 (GLUT9) and upregulated the renal expression levels of organic anion transporters (OAT1 and OAT3) in both HUA models. Thus, the findings of this study suggest that DTX suppresses the progression of HUA by modulating the expression of the UA transporter group members.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ameliorative action of “daitongxiao” against hyperuricemia includes the “uric acid transporter group”

Zheng,

Bai,

Wan

et al. 2024

Front. Pharmacol.

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“…A correlation analysis of the data is presented in Figure 6. It is assumed that the positively correlated metabolite pairs have similar chemical composition, biological function, and homogeneous characteristics [47]. The apricot kernel is placed separately from the plum and plum-apricot hybrid kernels.…”

Section: Principal Component and Hierarchical Cluster Analyses Of Hs-...mentioning

confidence: 99%

HS-SPME-GC–MS Profiling of Volatile Organic Compounds and Polar and Lipid Metabolites of the “Stendesto” Plum–Apricot Kernel with Reference to Its Parents

Mihaylova,

Popova,

Dincheva

et al. 2024

Horticulturae

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Plum–apricot hybrids are the successful backcrosses of plums and apricots. Plums and apricots are well-known and preferred by consumers because of their distinct sensory and beneficial health properties. However, kernel consumption remains limited even though kernels are easily accessible. The “Stendesto” hybrid originates from the “Modesto” apricot and the “Stanley” plum. Kernal metabolites exhibited quantitative differences in terms of metabolites identified by gas chromatography–mass spectrometry (GC–MS) analysis and HS-SPME technique profiling. The results revealed a total of 55 different compounds. Phenolic acids, hydrocarbons, organic acids, fatty acids, sugar acids and alcohols, mono- and disaccharides, as well as amino acids were identified in the studied kernels. The hybrid kernel generally inherited all the metabolites present in the parental kernels. Volatile organic compounds were also investigated. Thirty-five compounds identified as aldehydes, alcohols, ketones, furans, acids, esters, and alkanes were present in the studied samples. Considering volatile organic compounds (VOCs), the hybrid kernel had more resemblance to the plum one, bearing that alkanes were only identified in the apricot kernel. The objective of this study was to investigate the volatile composition and metabolic profile of the first Bulgarian plum–apricot hybrid kernels, and to provide comparable data relevant to both parents. With the aid of principal component analysis (PCA) and hierarchical cluster analysis (HCA), differentiation and clustering of the results occurred in terms of the metabolites present in the plum–apricot hybrid kernels with reference to their parental lines. This study is the first providing information about the metabolic profile of variety-defined kernels. It is also a pioneering study on the comprehensive evaluation of fruit hybrids.

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Floral dimorphism of Elsholtzia angustifolia (Loes.) Kitag. (Lamiaceae)

Jeon,

Moon,

Kong

et al. 2024

Flora

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GC-MS combined with multivariate analysis for the determination of the geographical origin of Elsholtzia rugulosa Hemsl. in Yunnan province

Abstract: Elsholtzia rugulosa Hemsl., a Chinese herbal medicine, may have the potential to treat COVID-19, and its geographical origin has been successfully identified by GC-MS combined with multivariate analysis.

Cited by 4 publications

References 33 publications

Ameliorative action of “daitongxiao” against hyperuricemia includes the “uric acid transporter group”

Ameliorative action of “daitongxiao” against hyperuricemia includes the “uric acid transporter group”

HS-SPME-GC–MS Profiling of Volatile Organic Compounds and Polar and Lipid Metabolites of the “Stendesto” Plum–Apricot Kernel with Reference to Its Parents

Floral dimorphism of Elsholtzia angustifolia (Loes.) Kitag. (Lamiaceae)

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