2018
DOI: 10.18632/aging.101535
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Abstract: Depression is concomitantly presented in hepatitis B virus (HBV)-infected patients (HB). However, there is still no objective method to diagnose HBV-infected patients with depression (dHB). Therefore, in this study, a gas chromatography-mass spectrometry (GC-MS)-based metabolomic approach was employed to profile urine samples from 59 dHB and 52 HB (the training set) in order to identify urinary metabolite biomarkers for dHB. Then, 41 dHB and 35 HB (the testing set) were used to independently validate the diagn… Show more

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Cited by 17 publications
(13 citation statements)
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References 34 publications
(36 reference statements)
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“…This panel had an excellent diagnostic performance in discriminating dHB subjects from HB subjects. Moreover, compared to the potential panels identified by single metabolomic platform, 12,13 this panel had a higher accuracy in diagnosing depression in HBV-infected patients. These results demonstrated that the complementary nature of NMR spectroscopy and GC-MS could provide a better and more specific panel in diagnosing dHB subjects than any single technique in isolation.…”
Section: Discussionmentioning
confidence: 95%
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“…This panel had an excellent diagnostic performance in discriminating dHB subjects from HB subjects. Moreover, compared to the potential panels identified by single metabolomic platform, 12,13 this panel had a higher accuracy in diagnosing depression in HBV-infected patients. These results demonstrated that the complementary nature of NMR spectroscopy and GC-MS could provide a better and more specific panel in diagnosing dHB subjects than any single technique in isolation.…”
Section: Discussionmentioning
confidence: 95%
“…Finally, 81 dHB subjects and 68 HB subjects extracted from our previous studies were included in this study. 12,13 All patients provided written informed consent, and that this study was conducted in accordance with the Declaration of Helsinki. The detailed information was described in Table 1.…”
Section: Patient Recruitmentmentioning
confidence: 99%
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“…Its exact pathogenesis is still unclear, although there are many theories attempting to explain it [3][4][5][6] . Meanwhile, its diagnosis still relies on subjective assessment of patient symptoms 7 , rather than on objective laboratory-based testing, although much work has been done to identify biomarkers for its objective diagnosis [8][9][10] . This may lead to underdiagnosis and misdiagnosis in primary care settings, where general practitioners make routine diagnoses of depression 11 .…”
Section: Introductionmentioning
confidence: 99%