Gaze, behavioral, and clinical data for phantom limbs after hand amputation from 15 amputees and 29 controls

Saetta, Gianluca; Cognolato, Matteo; Atzori, Manfredo; Faccio, Diego; Giacomino, Katia; Hager, Anne-Gabrielle Mittaz; Tiengo, Cesare; Bassetto, Franco; Müller, Henning; Brugger, Peter

doi:10.1038/s41597-020-0402-1

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…In literature, most studies reported that a majority of amputees continue to dream about themselves with an intact body [ 36 , 45 , 46 , 47 , 48 ] even if, in some cases, there is a difference between how the phantom limb is perceived in the waking state and in dreams [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

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Body Schema Self-Awareness and Related Dream Content Modifications in Amputees Due to Cancer

et al. 2021

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Purpose: the evaluation of body image perception, pain coping strategies, and dream content, together with phantom limb and telescoping phenomena in patients with sarcoma who underwent surgery for limb amputation. Material and Methods: consecutive outpatients were evaluated at T0 (within 3 weeks after surgery) and T1 (4–6 months after surgery) as follows: demographic and clinical data collection; the Groningen Questionnaire Problems after Arm Amputation; the West Haven-Yale Multidimensional Pain Inventory; the Body Image Concern Inventory, a clinical trial to identify telescoping; and a weekly diary of dreams. Dream contents were coded according to the Hall and Van de Castle coding system. Results: Twenty patients completed the study (15 males and 5 females, mean age: 53.9 ± 24.6, education: 7.8 ± 3.4). All subjects experienced phantom limb and 35% of them experienced telescoping soon after surgery, and 25% still after 4–6 months. Both at T0 and T1, that half of the subjects reported dreams about still having their missing limbs. At T1 the patients’ perceptions of being able to deal with problems were lower, and pain and its interference in everyday life were higher yet associated with significant engagement in everyday activities and an overall good mood. The dream content analysis highlighted that males were less worried about health problems soon after amputation, and women showed more initial difficulties that seemed to be resolved after 4–6 months after surgery. Conclusions: The dream content analysis may improve clinicians’ ability to support their patients during their therapeutic course.

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Section: Discussionmentioning

confidence: 99%

“…In amputees, phantom limb sensations and telescoping are widely present with most individuals experiencing some type of phantom phenomena at some point, post-amputation [ 26 , 27 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Body Schema Self-Awareness and Related Dream Content Modifications in Amputees Due to Cancer

et al. 2021

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“…Eye tracking reflects the user's visual attention and gaze direction [20], recorded from cameras or glasses that capture the movement of the eyes and pupils and processed by using methods such as gaze fixation, gaze switching, or gaze estimation to decode the user's intention [12,21]. Gaze fixation is used when the user is looking at a specific target for a certain amount of time and activating a corresponding hand gesture [22,23].…”

Section: Prosthetic Hands Controlmentioning

confidence: 99%

A Perspective on Prosthetic Hands Control: From the Brain to the Hand

Gentile,

Gruppioni

2023

Prosthesis

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The human hand is a complex and versatile organ that enables humans to interact with the environment, communicate, create, and use tools. The control of the hand by the brain is a crucial aspect of human cognition and behaviour, but also a challenging problem for both neuroscience and engineering. The aim of this study is to review the current state of the art in hand and grasp control from a neuroscientific perspective, focusing on the brain mechanisms that underlie sensory integration for hand control and the engineering implications for developing artificial hands that can mimic and interface with the human brain. The brain controls the hand by processing and integrating sensory information from vision, proprioception, and touch, using different neural pathways. The user’s intention can be obtained to control the artificial hand by using different interfaces, such as electromyography, electroneurography, and electroencephalography. This and other sensory information can be exploited by different learning mechanisms that can help the user adapt to changes in sensory inputs or outputs, such as reinforcement learning, motor adaptation, and internal models. This work summarizes the main findings and challenges of each aspect of hand and grasp control research and highlights the gaps and limitations of the current approaches. In the last part, some open questions and future directions for hand and grasp control research are suggested by emphasizing the need for a neuroscientific approach that can bridge the gap between the brain and the hand.

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“…The model’s limbs were pictured in the first-person (1pp, n = 128) or third-person (3pp, n = 128) perspective, and belonged to the object solidity constraint (n = 128) or limb solidity constraint (n = 128) condition. These two conditions were included on the basis of two strains of evidence: i) whether individuals with amputations show obstacle shunning or not depends on whether the phenomenal space occupied by the phantom limb overlaps with that of biological (i.e., the contraleral limb) or non biological (a wall) matter (Saetta et al, 2020a), and ii) obstacle shunning experience is related to LAMP (Saetta et al,. 2018).…”

Section: Studymentioning

confidence: 99%

“…Experienced by almost all individuals with an amputation (Ramachandran & Hirstein, 1998), phantom limb awareness refers to the persistence of the motor and postural representations of a limb despite its physical absence (Brugger, 2006). The phantom limb might be intentially moved to various degrees or completely immobilized (Saetta et al, 2020a). Training to execute impossible movements with a phantom limb has shown to enhance the visually guided perception of physically impossible movements, regardless of the SOAs (Moseley & Brugger, 2009).…”

Section: Introductionmentioning

confidence: 99%

Limb apparent motion perception: modification by tDCS, and clinically or experimentally altered bodily states

Saetta

Bekrater-Bodmann

et al. 2021

Preprint

Self Cite

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Limb apparent motion perception (LAMP) refers to the illusory visual perception of a moving limb upon observing two rapidly alternating photographs depicting the same limb in two different postures. Fast stimulus onset asynchronies (SOAs) induce the more visually guided perception of physically impossible movements. Slow SOAs induce the perception of physically possible movements. According to the motor theory of LAMP, the latter perception depends upon the observers' sensorimotor representations. Here, we tested this theory in two independent studies by performing a central (study 1) and peripheral (study 2) manipulation of the body"s sensorimotor states during two LAMP tasks. In the first sham-controlled transcranial direct current stimulation between-subject designed study, we observed that the dampening of left sensorimotor cortex activity through cathodal stimulation biased LAMP towards the more visually guided perception of physically impossible movements for stimulus pairs at slow SOAs. In the second, online within-subject designed study, we tested three participant groups twice: (1) individuals with an acquired lower limb amputation, either while wearing or not wearing their prosthesis; (2) individuals with body integrity dysphoria (i.e., with a desire for amputation of a healthy leg) while sitting in a regular position or binding up the undesired leg (to simulate the desired amputation); (3) able-bodied individuals while sitting in a normal position or sitting on one of their legs. We found that the momentary sensorimotor state crucially impacted LAMP in all groups. Taken together, the results of these two studies substantiate the motor theory of LAMP.

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Gaze, behavioral, and clinical data for phantom limbs after hand amputation from 15 amputees and 29 controls

Cited by 8 publications

References 42 publications

Body Schema Self-Awareness and Related Dream Content Modifications in Amputees Due to Cancer

Body Schema Self-Awareness and Related Dream Content Modifications in Amputees Due to Cancer

A Perspective on Prosthetic Hands Control: From the Brain to the Hand

Limb apparent motion perception: modification by tDCS, and clinically or experimentally altered bodily states

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