Abstract:β-lactam antibiotics are the most important and widely used antibacterial agents across the world. However, the widespread dissemination of β-lactamases among pathogenic bacteria limits the efficacy of β-lactam antibiotics. This has created a major public health crisis. The use of β-lactamase inhibitors has proven useful in restoring the activity of β-lactam antibiotics, yet, effective clinically inhibitors against class B metallo-β-lactamases (MBLs) are not available. L1, a class B3 enzyme expressed by Stenot… Show more
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