Gastroprotective xanthones isolated from Garcinia achachairu: Study on mucosal defensive factors and H+, K+-ATPase activity

Mariano, Luísa Nathália Bolda; Silva, Luísa Mota da; Souza, Priscila de; Boeing, Thaise; Somensi, Líncon Bordignon; Bonomini, Tiago José; Monachè, Franco Delle; Filho, Valdir Cechinel; Andrade, Sérgio Faloni de; Niero, Rivaldo

doi:10.1016/j.cbi.2016.08.009

Cited by 24 publications

(10 citation statements)

References 36 publications

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“…H + /K + ‐ATPase is the enzyme responsible to increase the liberation of protons, which allows the reduction of stomach pH and the activation of pepsin by the protons realized. In the healing process, one important factor is to control the gradient of the protons realized to H +/ K + ‐ATPase . HEBD inhibits the H +/ K + ‐ATPase consistently and similarly to the reference drug, omeprazole.…”

Section: Discussionmentioning

confidence: 99%

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p‐coumaric acid is a pivotal bioactive compound to this action

et al. 2019

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Baccharis dracunculifolia is a medicinal plant native to southeastern Brazil and is the main botanical source used by bees (Apis mellifera) in the manufacture of green propolis and display similar gastroprotective action and chemical profile. This article reports the healing gastric ulcer activity of the hydroethanolic extract of B. dracunculifolia (HEBD) in an acetic acid-induced ulcer model. In addition to the extract, the isolated compounds ferulic acid, p-coumaric acid, caffeic acid, baccharin, and aromadendrin-4'-O-methyl ether were also assayed. HEBD at a dose of 300 mg/kg reduced the ulcerated area by 49.4% after treatment for 7 days, twice a day. Histological analyses revealed that the margins and base of the ulcer obtained significant regeneration, and periodic acid Schiff base staining showed a 78.2% increase in the mucin levels. The action on the enzymatic antioxidant system demonstrated an increased activity of superoxide dismutase and glutathione-S-transferase, in addition to raising glutathione reduced levels and myeloperoxidase activity. HEBD did not show cytotoxicity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylterazole bromine test. In vitro, HEBD inhibited the H + /K + -ATPase enzyme and showed antioxidant activity in the 2,2 diphenyl-1-picryllydrazyl test. Regarding the isolated compounds, oral administration of p-coumaric acid (15 mg/kg) reduced the ulcerated area by 66.2%. The results suggest that HEBD recovers the gastric ulcerated tissue, raising mucus and antioxidant enzyme levels, and reducing the H + /K + -ATPase activity. In addition, the findings confirm that p-coumaric acid is a pivotal bioactive compound on the gastric healing effects elicited by HEBD. © 2019 BioFactors, 45(3):479-489, 2019

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Section: Discussionmentioning

confidence: 99%

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p‐coumaric acid is a pivotal bioactive compound to this action

et al. 2019

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“…The ascorbic acid content showed lower values in Garcinia gardneriana fruits (25.23 mg/100 g −1 ) in comparison with leaves (30.26 mg/100 g −1 ). Vitamin C is an important natural nutrient in daily diet [27]. Fruits offer several health benefits and are part of a group of foods rich in bioactive compounds, mainly antioxidants [28].…”

Section: Centesimal Composition and Antioxidant Activity Of Fruits Anmentioning

confidence: 99%

“…Vitamin C is as an important natural nutrient in the daily diet [27]. Fruits offer several health benefits and are part of a group of foods rich in bioactive compounds, mainly antioxidants [28].…”

Section: Garciniaphenonementioning

confidence: 99%

Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

et al. 2020

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The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of Garcinia gardneriana, a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were considered, along with an immortalized nontumor cell line. The antioxidant potential was determined, and the evaluation of antiradical air activity was performed. The levels of vitamin C and carotenoids were determined. The chemical profile was analyzed by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer using electrospray ionization interface. The chloroform fraction of the leaf showed antioxidant activity. The vitamin C content had lower values in fruits and higher in leaves. The content of carotenoids for fruits and leaves was expressive. The ethanolic extract and the hexane and chloroform fractions of fruits were active in all neoplastic lines tested. The leaves showed cytotoxic activity in the hexane fraction in the breast carcinoma line. The analysis of data obtained verified the presence of dimers, monomers, and tetramers of hexoses, polycarboxylic acids, xanthones, flavonoids, biflavonoids, and benzophenones.

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“…7 This kind of metabolites showed numerous pharmacological activities such as anti-cancer, 8 antioxidant, 9 diuresis and saluresis, 10 hepatoprotective, 11 anti-gout, 12 anti-inflammatory, 13 anti-diabetes, 14 and gastroprotective. 15 Recently, these xanthones easily incorporated into micro-molecules attributing to intriguing biological activities had drew attention from phytochemical, 16 organic synthesis, 17,18 and pharmacological endeavors. 19 Xanthones from the genus Garcinia had structural diversity and exhibited significant biological activity.…”

Section: Introductionmentioning

confidence: 99%

<p>Anti-Tumor Xanthones from <em>Garcinia nujiangensis</em> Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells</p>

Tang¹,

Lu²,

Xia³

2020

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Background: Ovarian cancer (OC) is a serious public health concern in the world. It is important to develop novel drugs to inhibit OC. Purpose: This study investigated the isolation, elucidation, efficiency, molecular docking, and pharmaceutical mechanisms of xanthones isolated from Garcinia nujiangensis. Methods: Xanthones were isolated, and purified by different chromatography, including silica gel, reversed-phase silica gel (ODS-C 18), and semipreparative HPLC, then identified by analysis of their spectral data. Three xanthones were estimated for their efficiency on the human OC cells HEY and ES-2. 2 was found to be the most potent cytotoxic xanthones of those tested. Further, its mechanisms of action were explored by molecular docking, cell apoptosis, and Western blotting analysis. Results: Bioassay-guided fractionation of the fruits of Garcinia nujiangensis led to the separation of a new xanthone named nujiangexanthone G (1) and two known xanthones. Among these, isojacareubin (2) exhibited the most potent cytotoxic compound against the HEY and ES-2 cell lines. The analysis of Western blot suggested that 2 inhibited OC via regulating the PARP, PI3K/ AKT/mTOR, and ERK/MAPK signal pathways in the HEY cell lines. Conclusion: In conclusion, isojacareubin (2) might be a potential drug for the treatment of OC.

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Gastroprotective xanthones isolated from Garcinia achachairu: Study on mucosal defensive factors and H+, K+-ATPase activity

Cited by 24 publications

References 36 publications

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p‐coumaric acid is a pivotal bioactive compound to this action

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p‐coumaric acid is a pivotal bioactive compound to this action

Antiproliferative Activity and Antioxidant Potential of Extracts of Garcinia gardneriana

<p>Anti-Tumor Xanthones from <em>Garcinia nujiangensis</em> Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells</p>

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