Gastroprotective, hepatoprotective, and nephroprotective effects of thymol against the adverse effects of acetylsalicylic acid in rats: Biochemical and histopathological studies

El-Sheikh, Sawsan M.A.; Bahaa, Hadeer M.; Galal, Azza A.A.; Metwally, Mohamed M.M.; Said, Mahmoud A.; Alattar, Reham H.; Fahmy, Esraa M.

doi:10.1016/j.sjbs.2022.103289

Cited by 4 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the tests in a comprehensive metabolic panel is the measurement of ALP levels, which can be high or low and suggest an underlying disease originating from the liver and bones 50 . The study revealed elevated ALP, AST, and ALT levels in the groups treated with cisplatin, suggesting potential hepatotoxicity in the animals.…”

Section: Hepatoprotective Effects Of Smedds-glementioning

confidence: 99%

Gynura procumbensLeaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

Shill,

Jalal,

Shuma

et al. 2024

Preprint

View full text Add to dashboard Cite

Gynura procumbens, known as longevity spinach, is a plant traditionally used in tropical Asian countries for its anti-inflammatory, hepatoprotective, anti-hypertensive, anti-hyperglycemic, and anti-inflammatory properties. The current study aimed to enhance the hepatorenal protective activity of Gynura procumbens leaf extract (GLE) by developing a self-microemulsifying drug delivery system (SMEDDS). SMEDDS-GLE exhibited the formation of small micelles with a mean droplet size of 231 nm. This resulted in a significant enhancement in the dispersion of GLE in water, as evidenced by a dispersibility that was at least 4.8 times greater than that of GLE alone. In the rat model of hepatic injury induced by cisplatin (7.5 mg/kg, i.p.), the administration of SMEDDS-GLE (75 mg-GLE/kg, p.o.) significantly reduced liver damage, observed by histological examination and reduced levels of plasma biomarkers associated with hepatic injury. Furthermore, according to histological examination findings and plasma biomarkers assessment, SMEDDS-GLE enhanced nephroprotective benefits of GLE in the rat model of acute kidney injury. Based on these findings, a strategic application of the SMEDDS-based approach could be a viable choice to enhance GLE's nutraceutical properties.

show abstract

Section: Hepatoprotective Effects Of Smedds-glementioning

confidence: 99%