Gastroprotective effect of apricot kernel oil in ethanol-induced gastric mucosal injury in rats

Karaboğa, İhsan; Ovalı, Mehmet Akif; Yılmaz, Ahsen; Alpaslan, Mehmet

doi:10.1080/10520295.2018.1511064

Cited by 23 publications

(14 citation statements)

References 27 publications

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“…The present study demonstrated gastroprotective and anti-inflammatory effects of diosgenin against gastric mucosal damage due to HCl/ethanol in rats for the first time. Similar to the previous studies, HCl/ethanol administration caused severe gastric mucosal damage that was observed through gastric ulcer index and histopathological changes with signs of epithelial cell loss, submucosal edema, and hemorrhage [ 23 , 24 ]. Intragastric administration of diosgenin significantly reversed the HCl/ethanol-induced gastric mucosal damage as demonstrated in the results.…”

Section: Discussionsupporting

confidence: 79%

“…Intragastric administration of diosgenin significantly reversed the HCl/ethanol-induced gastric mucosal damage as demonstrated in the results. The gastroprotective effects of diosgenin have similar findings with other bioactive compounds tested in past studies against chemically induced gastric injury in animal models [ 23 , 24 , 25 , 26 , 27 ]. The gastroprotective results of the reported bioactive compounds are associated with their antioxidant and anti-inflammatory effects.…”

Section: Discussionsupporting

confidence: 70%

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Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Zhao

Zhang

et al. 2021

Open Life Sciences

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Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties. The aim of this study is to explore the gastroprotective role of diosgenin on gastric mucosal damage caused by HCl/ethanol in rats. Male Sprague-Dawley rats were intragastrically administered with diosgenin (20 mg/kg) before HCl/ethanol (0.15 M HCl in 98 % ethanol) administration. Omeprazole was used as a positive control. Diosgenin-attenuated oxidative stress by enhancing (p < 0.05) antioxidant enzymes, reducing lipid peroxidation (MDA), and modulating nitric oxide (NO) levels. Anti-inflammatory effects of diosgenin were observed by a reduction in pro-inflammatory cytokines (p < 0.05), decreased myeloperoxidase (MPO) activities (p < 0.05), and histopathological observation of gastric mucosal damage. Western blot analysis provided evidence on the downregulation of NF-κβ by diosgenin. The findings showed that diosgenin has a significant protective role on gastric injury caused by HCl/ethanol, through its antioxidant, anti-inflammatory role, and suppression of NF-κβ and MPO activities.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 70%

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Zhao

Zhang

et al. 2021

Open Life Sciences

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“…Prunus armeniaca L. (Rosaceae) kernel oil, "apricot", also showed a gastroprotective effect on ethanol-induced gastric ulcer in rats by its anti-inflammatory, antioxidant, and anti-apoptotic effects, as observed by a decreased number of iNOS and TUNEL positive cells and MDA and IL-6 levels in the gastric mucosa [49].…”

Section: Gastroprotective Plants With Anti-apoptotic Effectsmentioning

confidence: 99%

Herbal Medicines in the Treatment of Dyspepsia: An Overview

et al. 2021

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This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.

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“…The apricot (Prunus armeniaca L.) belongs to the Rosaceae, a family with almost 175 species, which is native to China and Japan, but commercially planted in the warmer temperate regions, such as Turkey, Iran and Italy (Gomaa, 2013;Korekar et al, 2011). Because of the significant amounts of compounds such as sterols, tocopherols, b -carotene, vitamin A and lycopene, sweet apricot kernel exhibits a wide range of biological activities (Rudzi nska et al, 2017;Karabo ga et al, 2018;Slover et al, 1983). Sweet apricot kernel has been used in folk medicine to treat various diseases such as ulcers, vaginal infections and tumors (Rai et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Sweet apricot kernel has been used in folk medicine to treat various diseases such as ulcers, vaginal infections and tumors (Rai et al, 2016). In previous studies, several pharmacological properties of sweet apricot kernel have been reported, including antimicrobial (Yi git et al, 2009;Gomaa, 2013;Popa et al, 2011), anti-inflammatory (Karabo ga et al, 2018) and antioxidant activities (Korekar et al, 2011;Yi git et al, 2009). Moreover, it has been reported that sweet apricot kernel ethanolic extract (SAEE) shows antitumor activity against human breast (MCF-7), colon (HCT-116) and hepatocellular (Hep-G2) carcinoma cell lines (Gomaa, 2013).…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of cytotoxic and apoptotic activities of ethanolic extract of sweet apricot kernel on PANC-1 pancreatic cancer cells

Aamazadeh

Barar

Saadat

et al. 2021

NFS

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Purpose This study aimed to evaluate the cytotoxic/apoptotic effects of sweet apricot kernel ethanolic extract (SAEE) on human cancerous PANC-1 and 293/KDR normal cells. Design/methodology/approach The extract was prepared by maceration, and its chemical composition was analyzed by gas chromatography-mass spectrometry (GC-MS). The biological effects of SAEE on PANC-1 and 293/KDR cells were investigated using MTT (3–(4, 5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide) assay, DAPI (4',6-diamidino-2-phenylindole) and AnnexinV/propidium iodide (PI) staining. The expression of pro- and anti-apoptotic genes was evaluated by real-time quantitative polymerase chain reaction (real-time q-PCR) analysis. Findings The SAEE showed the selective growth inhibitory activity against PANC-1 cells with an IC50 (the 50% inhibitory concentration) value of about 1 mg/mL at 72 h. Further investigations by DAPI staining and flow cytometry revealed nucleus fragmentation and elevation of apoptotic cells, respectively. Also, a significant decrease in B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated x protein (Bax) ratio (0.41, p = 0.001) and the up-regulation of caspase-3 expression (1.5 fold, p = 0.002) indicated the induction of apoptosis in PANC-1 cells but not in 293/KDR non-cancerous cells. These results suggest that SAEE could induce apoptosis in cancer cells via a mitochondrial dependent pathway. Furthermore, GC-MS analysis showed that the SAEE is rich in γ-sitosterol and γ-tocopherol. Overall, the findings suggest that because of the selective impacts of SAEE on PANC-1 cells, it can be considered as a supportive care in adjuvant therapy for pancreatic cancer. However, the potent anticancer effects of main components of SAEE and its clinical value as an antitumor drug should be further investigated. Research limitations/implications Considerable limitations of this study were that the related mechanisms of selective impacts of SAEE on cancerous and normal cells and potent cytotoxic/apoptotic effects of γ-sitosterol and γ-tocopherol as major components of SAEE were not investigated. Originality/value Recently, a growing interest has been dedicated to plant-based natural products. Sweet apricot kernel exerts a number of pharmacological activities; however, the anticancer effect, related mechanisms and its active compounds were rarely investigated. In this study, the authors aimed to evaluate the cytotoxic/apoptotic effects of SAEE on human cancerous PANC-1 and 293/KDR normal cells.

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Gastroprotective effect of apricot kernel oil in ethanol-induced gastric mucosal injury in rats

Cited by 23 publications

References 27 publications

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Herbal Medicines in the Treatment of Dyspepsia: An Overview

In vitro evaluation of cytotoxic and apoptotic activities of ethanolic extract of sweet apricot kernel on PANC-1 pancreatic cancer cells

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