Gastroprotective effect methanol extract of Caesalpinia coriaria pods against indomethacin- and ethanol-induced gastric lesions in Wistar rats

Pineda-Peña, Elizabeth Arlen; Capistran-Amezcua, David; Reyes-Ramírez, Adelfo; Xolalpa-Molina, Santiago; Chávez-Piña, Aracely Evangelina; Figueroa, Mario; Navarrete, Andrés

doi:10.1016/j.jep.2022.116057

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…Rojas-Morales et al [39] reported values for condensed and total tannins of 13 and 34 mg/gdw, respectively. A total condensed tannins content of 7.72 mg/gdw was reported by Pineda-Peña et al [40]. The values for condensed and total polyphenols released from cascalote pods in the present work are 120-521% and 265-288% higher than the values previously reported [38][39][40].…”

Section: Discussioncontrasting

confidence: 52%

“…The RP-HPLC-ESI-MS of cascalote extracts showed that the main compounds were 5-O-galloylquinic acid, ellagic acid derivatives, corilagin, gallagyl-hexoside, lagerstannin B derivative, geraniin, and ellagic acid. There have been no reports indicating the identification of phenolic compounds obtained from cascalote pods by SSF; however, some of these compounds have been previously reported from the hydroalcoholic extracts of C. coriaria [40,42]. In addition, other compounds, such as ethyl gallate, methyl gallate, gallic acid, tetragalloylglucose, pentagalloylglucose, valoneic acid dilactone, digalloylshikimic acid, and other phenolic compound derivatives, have been cited [2,4,43].…”

Section: Discussionmentioning

confidence: 99%

“…Identified polyphenol molecules in cascalote pods have different biological activities, such as antioxidant effects, hepatoprotective effects [41], anthelmintic effects [39,44], arginase inhibitory activity [45], antimicrobial activity [4,43,46], and gastroprotective effects [40]. These benefits provide a wide range of possible applications in the food, pharmaceutical, and cosmetic industries.…”

Section: Discussionmentioning

confidence: 99%

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Solid-State Fermentation as a Sustainable Tool for Extracting Phenolic Compounds from Cascalote Pods

López-Cárdenas,

Ochoa-Reyes,

Baeza-Jiménez

et al. 2023

Fermentation

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Cascalote pods are an important source of phenolic compounds, mainly recovered using solvent extraction methods. To find a sustainable alternative to these methods, this study aimed to evaluate solid-state fermentation (SSF) in order to enhance the extractability of total phenolic compounds (TPC) with antioxidant activity (AA) from cascalote pods. Aspergillus niger GH1 was selected based on the amount of TPC released and AA measured (ABTS, DPPH, FRAP) in a short period of time. Moreover, moisture, temperature, inoculum size, and mineral composition were evaluated. The largest amount of TPC released was 124.17 mg/gdw (g of dry weight) after 12 h of culture, which significantly correlated with the AA (Pearson’s R = 0.94). Moisture and KH2PO4 concentration were the main influencing factors of TPC release. Treatment 6 (1 × 107 spores/gdw, 30 °C, 60% moisture, mineral composition (g/L): KH2PO4, 1.52; NaNO3, 7.65; and MgSO4, 1.52) was selected due to the highest values of both TPC and AA. SSF-assisted extraction allowed for an increase of 118% and 93% in TPC and AA values, respectively. Corilagin, lagerstannin, geraniin, and ellagic acid were the main phenolic compounds identified by RP-HPLC-ESI-MS in the cascalote extracts. The results obtained demonstrate the feasibility of SSF-assisted extraction as a biotechnological alternative for the recovery of important bioactive molecules from this underutilized material.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Solid-State Fermentation as a Sustainable Tool for Extracting Phenolic Compounds from Cascalote Pods

López-Cárdenas,

Ochoa-Reyes,

Baeza-Jiménez

et al. 2023

Fermentation

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“…LTB4 can attract and activate other white blood cells, such as neutrophils, to sites of inflammation, thereby exacerbating the inflammatory response. It has been previously reported that non-steroidal anti-inflammatory drugs such as indomethacin can cause leukocyte infiltration and increase the level of leukotriene B4 in the stomach, thereby activating inflammatory pathways to attack gastric tissue [ 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

LC-MS-Based Metabolomics Reveals the Mechanism of Protection of Berberine against Indomethacin-Induced Gastric Injury in Rats

Xu,

Yang

2024

Molecules

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Berberine is a natural isoquinoline alkaloid with low toxicity, which exists in a wide variety of medicinal plants. Berberine has been demonstrated to exhibit potent prevention of indomethacin-induced gastric injury (GI) but the related mechanism remains unclear. In the present study, liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was applied for the first time to investigate the alteration of serum metabolites in the protection of berberine against indomethacin-induced gastric injury in rats. Subsequently, bioinformatics was utilized to analyze the potential metabolic pathway of the anti-GI effect of berberine. The pharmacodynamic data indicated that berberine could ameliorate gastric pathological damage, inhibit the level of proinflammatory factors in serum, and increase the level of antioxidant factors in serum. The LC-MS-based metabolomics analysis conducted in this study demonstrated the presence of 57 differential metabolites in the serum of rats with induced GI caused by indomethacin, which was associated with 29 metabolic pathways. Moreover, the study revealed that berberine showed a significant impact on the differential metabolites, with 45 differential metabolites being reported between the model group and the group treated with berberine. The differential metabolites were associated with 24 metabolic pathways, and berberine administration regulated 14 of the 57 differential metabolites, affecting 14 of the 29 metabolic pathways. The primary metabolic pathways affected were glutathione metabolism and arachidonic acid metabolism. Based on the results, it can be concluded that berberine has a gastroprotective effect on the GI. This study is particularly significant since it is the first to elucidate the mechanism of berberine’s action on GI. The results suggest that berberine’s action may be related to energy metabolism, oxidative stress, and inflammation regulation. These findings may pave the way for the development of new therapeutic interventions for the prevention and management of NSAID-induced GI disorders.

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“…The stomachs were rapidly removed, opened along their greater curvature, and cleaned gently by dipping them in saline. The mucosal damage was examined grossly under magnifying lens 14 . The severity of mucosal damage was assessed by modifying a previously reported 15 -rating scale.…”

Section: Group Bmentioning

confidence: 99%

Untitled

2023

IJPSR

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Proton Pump Inhibitors (PPIs) are widely used acid suppression medications for many conditions. PPIs class includes many drugs, such as omeprazole, lansoprazole, pantoprazole and esomeprazole, available orally in a tablet/capsule form. PPI's products have reasonably high prices with quality differences that most healthcare providers must know. Therefore, this study aimed to compare the quality of PPIs for brand and generics in the Saudi market. Gastric ulcers result from an imbalance involving gastric protection and aggressive factors. Gastric protection depends on several factors, such as the release of prostaglandin E2 (PGE2), bicarbonate secretion, gastric mucus production, and gastric mucosal blood flow regulation. Factors leading to gastric offensives are the hypersecretion of H.C.L. or pepsin. Ethanol is well known to induce gastric ulcers via multi-factorial mechanisms such as the impairment of gastric defensive factors like mucus dissolution or by increasing offensive factors such as acid secretion or gastrin release. Our study reveals that the gastroprotective effect of PPIs marketed in Saudi Arabia has significantly protected the gastric mucosa against ethanol challenge. INTRODUCTION:The first proton pump inhibitor discovered was omeprazole. Initially, it was only a chemical structure with an observed antisecretory effect and severe toxic effect. However, basic and applied research operated together to reach an acceptable balance between the efficacy and safety of omeprazole 1 .

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Gastroprotective effect methanol extract of Caesalpinia coriaria pods against indomethacin- and ethanol-induced gastric lesions in Wistar rats

Cited by 8 publications

References 45 publications

Solid-State Fermentation as a Sustainable Tool for Extracting Phenolic Compounds from Cascalote Pods

Solid-State Fermentation as a Sustainable Tool for Extracting Phenolic Compounds from Cascalote Pods

LC-MS-Based Metabolomics Reveals the Mechanism of Protection of Berberine against Indomethacin-Induced Gastric Injury in Rats

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