Gastroprotective and Immuno-supportive Role of Alcea kurdica against Stress Induced Lesion in Japanese Quails

Abstract

The conducted research was done in Grda rasha field (Salahaddin University) for one month to compare the impacts of Alcea kurdica powder, Rifaxmine, and Ranitidine as anti-lesion and immune-strengthening agents on stress-induced quails which are affecting their growth rate and in severe cases causing gizzard erosion and deep intestinal lesions. To do that, 75 quails (12 weeks old) were grouped into six treatments with different additives. (T0-) = Negative control (Stress-induced Without treatment), (T0+) = Positive control (No stress inducing or treatment). T1= (treated with Rifaximine 200mg/L water mixed), T2= (treated with Ranitidine 200mg/L), T3= (treated with A.kurdica extract 100mg/L). The tested groups, except for positive control, were immersed in tap cold water (17°C) as a stress-induced technique. The Macroscopic analysis showed that quails pre-treated with A.kurdica extract (T3) had significantly (p<0.05) lower relative gizzard koilin layer disruption than those of T1, T2, and T0-groups, respectively. Moreover, the Elisa results indicated higher antibody titers against ND, IBD, and IB viruses for the T3 group with significantly increased HDL and lowered LDL, VLDL, and TCHO for T3 than that of T1, T2, T0+ T0-groups, respectively. Water mixed A.kurdica extract showed positive influences on the body weight, lipid profile, immune status and minimized gizzard erosions of breeding quails, which can be considered as a medicinal plant as well as a growth-enhancing agent in the poultry industry.

Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants

“…55 IBD is a digestive tract disease that mainly affects the large intestine and can be originated from genetic and oxidative stress (key pathophysiological) risk factors. 45 IBD primarily includes Crohn's disease and ulcerative colitis, which are similar in terms of originating from immunologic overreaction and different from each other based on their involvement in the digestive system. 56 Moreover, oxidative stress studies have shown the transformation of sensory cells into neoplastic cells in many IBD cases.…”

“…The supernatant was moved into separate tubes and investigated for the antioxidant enzymes (CAT, SOD and GPX) and MDA content (kits from Elabscience, USA). 45 …”

Antiulcerogenic activities of Heterotis rotundifolia (Sm.) Jacq. Fel extract and fractions and their phytochemical constituents

“…et al Flavonoids protect the gastric mucosa from damage by increasing the mucosal prostaglandin content and by inhibiting histamine secretion. Phenolics and terpenoids have played a substantial role in the development of human medicine as antioxidants, and through their free radical scavenging, and gastroprotective actions (Enin ., et al 2021b;Jabbar, 2022;Li ., 2022). In this study, we et al summarized therefore, that these chemical compounds which are found to be present in this extract and fractions may be responsible for the observed antiulcerogenic activities…”

Phytochemical profile, Antioxidant, Enzyme inhibitory and acute toxicity activity of Astragalus bruguieri

“…antioxidant 4,14,17,32 . The phenolic compounds are also linked with improving defense mechanisms through reversing ROS formation, increasing cell survival, and decreasing nuclear damages and microorganism attacks [38][39][40][41] .…”