Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: Role of proinflammatory cytokines and oxidative damage

Jainu, Mallika; Devi, C. S. Shyamala

doi:10.1016/j.cbi.2006.04.011

Cited by 94 publications

(53 citation statements)

References 26 publications

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“…Moreover, G. sylvestre treatment significantly inhibited the total gastric secretion and acidity output during 6 h following hypersecretion model by pylorus ligature in dose-dependent manner. Indeed, these results are in agreement with earlier study done with similar constituents, which showed a decrease in gastric secretion protection against experimentally induced gastric damage in animal models (Jainu & Devi, 2006;Navarrete et al, 2002;Sairam et al, 2002).…”

Section: Discussionsupporting

confidence: 93%

“…Literature survey revealed that the major bioactive constituents of G. sylvestre leaves are a group of oleanane type triterpenoid saponins known as gymnemic acids (Kanetkar et al, 2007;Ye et al, 2000), alkaloids, acidic glycosides and anthroquinones and their derivatives (Surveswaran et al, 2010). All of these phytoconstituents are known to offer protection against experimentally induced gastric damage in animal models (Jainu & Devi, 2006;Navarrete et al, 2002;Sairam et al, 2002). Moreover, saponins and their triterpene derivatives have been found to promote ulcer healing by forming a protective mucus barrier on the gastric mucosa (Oyagi et al, 2010;Zakaria et al, 2011).…”

mentioning

confidence: 99%

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Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage byGymnema sylvestrein male Wistar albino rats

Al‐Rejaie

Abuohashish²,

Ahmed

et al. 2012

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage byGymnema sylvestrein male Wistar albino rats

Al‐Rejaie

Abuohashish²,

Ahmed

et al. 2012

Pharmaceutical Biology

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“…The under trial drug Cissus quadrangularis has a gastroprotective property so the incidences of epigastric pain or abdominal pain were less or none in treated group as compared to control group. 8 Cissus quadrangularis contains mostly carbonates and to a smaller extent phosphates of sodium, potassium, magnesium and calcium. Presence of potassium tartarate is also reported.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Hormonal Evaluation of Cissus Quadrangularis in Accelerating Healing Process of Bone Fracture: A Clinical Study

Rasale¹,

Raut²,

Narkhede³

et al. 2014

Int. J. Res. Ayurveda Pharm.

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Repair of bone defects secondary to trauma, osteoporosis, osteomyelitis and fracture nonunion poses a significant problem for many orthopedicians. As a part of our continuing screening of biologically active natural fracture healing accelerating agents, drug Asthishrunkhala reported to contain phytoestrogenic steroids, ascorbic acid, carotene, calcium, and anabolic steroids and shown to heal the bone fractures in several in vivo studies. Therefore, a random controlled study was conducted with the aim to evaluate the effective remedial therapy to accelerate bone healing so as to rehabilitate the individual as early as possible. Fracture healing was assessed with biochemical parameters like serum calcium, serum phosphorus and a hormonal parameter PTH (parathyroid hormone) and their values were evaluated during fracture healing. From the assessed data it was found that bone healing process was accelerated as serum level of PTH Hormone have shown increasing trend during the period of 31 days and it was at its peak on 21 st day from inception of administration of drug; but levels of calcium and phosphorus were remain maintained during period of fracture healing. In control group it was observed that serial values of Serum Calcium, Serum Phosphorus and PTH Hormone were not having significant fluctuations. This indicates that the process of fracture healing or osteoblastic activity was initiated earlier in trial group. Hence study concludes that the drug Cissus quadrangularis is having influence on accelerating the fracture healing process and further it helps in reducing period of immobilization and early rehabilitation.

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“…Extracts of C. quadrangularis roots have been used traditionally in the treatment of inflammation and pain in which the plant functions as an anti-inflammatory agent and analgesic (Shanthi et al, 2010;Anoop and Jagdeesan, 2006;Jainu and Devis, 2004;Jainu and Chennam, 2006;Jainu and Chennam, 2005;Jainu and Devis, 2003;Evans, 2001;Attawish et al, 2002). The aim of this study was to investigate the therapeutic effects of ethanol root extract of C. quadrangularis against indomethacin and ethanolinduced ulcer in rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of ethanol extract of Cissus quadrangularis on induced gastric ulcer in rats

Enechi¹,

C²,

Igbonekwu³

et al. 2013

Afr. J. Biotechnol.

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Antiulcer activities of the ethanol extract of Cissus quadrangularis roots on indomethacin and ethanolinduced gastric ulcers were investigated. The results obtained show that the ulceration in gastric linings of the stomach of rats pre-treated with the C. quadrangularis extract before induction with ethanol and indomethacin decreased significantly when compared to the control. The protective effect of the extract increased in a dose-dependent manner in both ulcer models. There were significant decreases (p <0.05) in the number of ulcer lesions when rats were administered with the graded doses of the extract and ranitidine (100 mg/kg body weights) compared with the control groups in both models. Results from this study suggest that the extract of C, quadrangularis roots possesses antiulcer activities.

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Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: Role of proinflammatory cytokines and oxidative damage

Cited by 94 publications

References 26 publications

Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage byGymnema sylvestrein male Wistar albino rats

Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage byGymnema sylvestrein male Wistar albino rats

Biochemical and Hormonal Evaluation of Cissus Quadrangularis in Accelerating Healing Process of Bone Fracture: A Clinical Study

Effects of ethanol extract of Cissus quadrangularis on induced gastric ulcer in rats

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